Recombinant Proteins iso9001 ISO13485
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 > 【Integrin alpha V beta 1】重组蛋白信息

Integrin alpha V beta 1信息

英文名称:Integrin alpha-V/beta-1
中文名称:整合素α-V/β-1复合体
靶点别称
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

Integrin alpha V beta 1 Molecule Synonym Name

Integrin alpha V beta 1,ITGAV&ITGB1

Integrin alpha V beta 1 分子背景

Integrin alpha-5/beta-1 is a receptor for ibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-V/beta-1 is also a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.

Integrin alpha V beta 1 参考文献

Integrin alpha V beta 1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
VAX-014 VAX-014 临床一期 Vaxiion Therapeutics 膀胱癌 详情
PLN-1474 PLN-1474 临床一期 Pliant Therapeutics, 诺华制药 非酒精性脂肪肝, 肝硬化 详情
IDL-2965 IDL-2965 临床二期 Indalo Therapeutics 非酒精性脂肪肝, 特发性肺纤维化 详情
PLN-74809 PLN-74809 临床二期 Pliant Therapeutics 特发性肺纤维化, 新型冠状病毒肺炎, 成人呼吸窘迫综合征, 原发性硬化性胆管炎 详情

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