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IL-37产品列表

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物种
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属性
货号 物种 产品描述 蛋白结构 纯度 活性
ILB-H5141
Human
Human IL-37b / IL-1F7b Protein, His Tag
ILB-H51H5
Human
Human IL-37 / IL-1F7 Protein, His Tag
 
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IL-37 分子别名

IL1F7,IL37,FIL1Z,IL1H4,IL1RP1

IL-37 分子背景

Interleukin-1 family member 7 (IL1F7b) ,a member of the IL-1 family, is aslo known as interleukin-37, interleukin-1 homolog 4 (IL-1H4), interleukin-1 zeta (IL-1 zeta) and interleukin-1-related protein, which can interact with SMAD3 and bind to IL18R1, but not to IL1R1, with lower affinity than IL18. IL1F7b is a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Therefore,IL1F7b can suppress, or reduce, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spare anti-inflammatory cytokines. Furthermore,IL1F7b can also inhibit dendritic cell activation.

IL-37 前沿进展

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