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IL-33信息

英文名称:Interleukin-33
中文名称:白细胞介素-33
靶点别称:Nuclear Factor For High Endothelial Venules,DVS27-Related Protein,IL1F11,IL33,Interleukin-1 family member 11,IL-1F11,Interleukin 33,Nuclear Factor From High Endothelial Venules,C9orf26,NF-HEV,Chromosome 9 Open Reading Frame 26 (NF-HEV),Interleukin-1 Famil
上市药物数量:0
临床药物数量:4
最高研发阶段:临床三期

IL-33产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
IL3-H52H7
Human
Human IL-33 Protein, His Tag
IL3-C5245
Cynomolgus
Cynomolgus IL-33 Protein, His Tag
IL3-M5245
Mouse
Mouse IL-33 Protein, His Tag (MALS verified)
IL3-H82H5
Human
Biotinylated Human IL-33 Protein, His,Avitag (MALS verified)
IL3-C52H3
Canine
Canine IL-33 Protein, His Tag
 
评论(2)
IL3-H52H7|Human IL-33 Protein, His Tag
  1. 江苏荃信生物医药有限公司
  2. 0人赞
  3. 项目立项阶段,我们对比了多种品牌的IL-33,最终选择了ACRO的IL-33作为免疫原,并在克隆筛选阶段及后续的方法开发中,作为固定用的试剂,建立的筛选方法稳定可靠。
  4. 2021-05-18
IL3-H52H7|Human IL-33 Protein, His Tag
  1. 138XXXXXXX6
  2. 2人赞
  3. 用这个蛋白,摸索和建立实验方法,做抗体筛选,涉及到的实验方法,Elisa筛选,流式检测,octet测定抗体的binding和竞争实验,蛋白很好用,实验结果达到预期,经常买你家的蛋白。
  4. 2019-09-26
 

IL-33 分子别名

IL33,DV27,C9ORF26,IL1F11,NFHEV,DKFZp586H0523,DVS27,NFEHEV,RP11-575C20.2

IL-33 分子背景

Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.

IL-33 参考文献

IL-33临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
PF-06817024 PF-06817024 临床一期 辉瑞 鼻疾病, 鼻窦炎, 特应性皮炎 详情
LY-3375880 LY-3375880 临床二期 礼来制药 特应性皮炎 详情
Anti-IL-33 mAb (Regeneron Pharmaceuticals/Sanofi) REGN-3500; SAR-440340 临床三期 Regeneron Pharmaceuticals Inc, 赛诺菲 哮喘, 慢性阻塞性肺疾病, 特应性皮炎 详情
Etokimab ANB-020 临床二期 Anaptysbio 肺嗜酸粒细胞增多, 鼻窦炎, 哮喘, 花生过敏, 特应性皮炎, 超敏反应 详情

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