IL-33 靶点蛋白|抗体药物|临床药物信息

IL-33信息

英文名称：Interleukin-33
中文名称：白细胞介素-33
靶点别称：Nuclear Factor For High Endothelial Venules，DVS27-Related Protein，IL1F11，IL33，Interleukin-1 family member 11，IL-1F11，Interleukin 33，Nuclear Factor From High Endothelial Venules，C9orf26，NF-HEV，Chromosome 9 Open Reading Frame 26 (NF-HEV)，Interleukin-1 Family， Member 11，NFEHEV，DVS27，IL-33，NFHEV，Interleukin-33，DKFZp586H0523

上市药物数量：0
临床药物数量：5
最高研发阶段：临床三期

IL-33产品列表

筛选结果

产品库

在线 (5)

物种

标签

属性

Protein (5)

标记

货号	物种	产品描述
IL3-H52H7	Human	Human IL-33 Protein, His Tag
IL3-C5245	Cynomolgus	Cynomolgus IL-33 Protein, His Tag (MALS verified)
IL3-M5245	Mouse	Mouse IL-33 Protein, His Tag
IL3-H82H5	Human	Biotinylated Human IL-33 Protein, His,Avitag™ (MALS verified)
IL3-M82Q7	Mouse	Biotinylated Mouse IL-33 Protein, His,Avitag™ (MALS verified)

IL3-C5245|Cynomolgus IL-33 Protein, His Tag (MALS verified)

139XXXXXXX9

1人赞

该产品用于杂交瘤抗体筛选，需要得到不同种属靶点cross binding的leads，该抗体是通过ELISA进行筛选的，数据显示亲和力良好。
2021-08-13

IL3-H52H7|Human IL-33 Protein, His Tag

江苏荃信生物医药有限公司

5人赞

项目立项阶段，我们对比了多种品牌的IL-33，最终选择了ACRO的IL-33作为免疫原，并在克隆筛选阶段及后续的方法开发中，作为固定用的试剂，建立的筛选方法稳定可靠。
2021-05-18

IL3-H52H7|Human IL-33 Protein, His Tag

187XXXXXXX5

3人赞

大包装性价比超级高，当然了价格方面是一个公司最大的考虑因素，也是阻碍科学实验的根本原因，该蛋白在动物免疫领域的优势很明显，蛋白很稳定，质量很好
2020-04-22

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IL-33 分子别名

IL33,DV27,C9ORF26,IL1F11,NFHEV,DKFZp586H0523,DVS27,NFEHEV,RP11-575C20.2

IL-33 分子背景

Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.

IL-33 前沿进展

IL-33临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
PF-06817024	PF-06817024	临床一期	辉瑞	鼻疾病, 鼻窦炎, 特应性皮炎	详情
MT-2990	MT-2990	临床二期	Mitsubishi Tanabe Pharma Corp	季节性过敏性鼻炎, 疼痛, 自身免疫疾病, 炎性疾病	详情
Itepekimab	REGN-3500; SAR-440340	临床三期	Regeneron Pharmaceuticals Inc, 赛诺菲	哮喘, 慢性阻塞性肺疾病, 特应性皮炎	详情
Torudokimab	LY-3375880	临床二期	礼来制药	特应性皮炎	详情
Etokimab	ANB-020	临床二期	Anaptysbio	肺嗜酸粒细胞增多, 鼻窦炎, 哮喘, 花生过敏, 特应性皮炎, 超敏反应	详情

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IL-33