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> 【IL-33】
IL-33信息
英文名称：Interleukin-33
中文名称：白细胞介素-33
靶点别称：Nuclear Factor For High Endothelial Venules，DVS27-Related Protein，IL1F11，IL33，Interleukin-1 family member 11，IL-1F11，Interleukin 33，Nuclear Factor From High Endothelial Venules，C9orf26，NF-HEV，Chromosome 9 Open Reading Frame 26 (NF-HEV)，Interleukin-1 Family， Member 11，NFEHEV，DVS27，IL-33，NFHEV，Interleukin-33，DKFZp586H0523
中文名称：白细胞介素-33
靶点别称：Nuclear Factor For High Endothelial Venules，DVS27-Related Protein，IL1F11，IL33，Interleukin-1 family member 11，IL-1F11，Interleukin 33，Nuclear Factor From High Endothelial Venules，C9orf26，NF-HEV，Chromosome 9 Open Reading Frame 26 (NF-HEV)，Interleukin-1 Family， Member 11，NFEHEV，DVS27，IL-33，NFHEV，Interleukin-33，DKFZp586H0523
上市药物数量：0
临床药物数量：5
最高研发阶段：临床三期
临床药物数量：5
最高研发阶段：临床三期
IL-33产品列表
产品库
属性
评论(6)
IL3-H52H7|Human IL-33 Protein, His Tag (MALS verified)
- 138XXXXXXX6
- 用这个蛋白，摸索和建立实验方法，做抗体筛选，涉及到的实验方法，Elisa筛选，流式检测，octet测定抗体的binding和竞争实验，蛋白很好用，实验结果达到预期，经常买你家的蛋白。
- 2019-09-26
5人赞
IL3-H52H7|Human IL-33 Protein, His Tag (MALS verified)
- 江苏荃信生物医药有限公司
- 项目立项阶段，我们对比了多种品牌的IL-33，最终选择了ACRO的IL-33作为免疫原，并在克隆筛选阶段及后续的方法开发中，作为固定用的试剂，建立的筛选方法稳定可靠。
- 2021-05-18
5人赞
IL3-H52H7|Human IL-33 Protein, His Tag (MALS verified)
- 187XXXXXXX5
- 大包装性价比超级高，当然了价格方面是一个公司最大的考虑因素，也是阻碍科学实验的根本原因，该蛋白在动物免疫领域的优势很明显，蛋白很稳定，质量很好
- 2020-04-22
3人赞
IL-33 分子别名
IL33,DV27,C9ORF26,IL1F11,NFHEV,DKFZp586H0523,DVS27,NFEHEV,RP11-575C20.2
IL-33 分子背景
Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.
IL-33 前沿进展
IL-33临床药物信息
| 英文名称 | 研发代码 | 研发阶段 | 公司 | 适应症 | 临床试验 |
|---|---|---|---|---|---|
| Torudokimab | LY-3375880 | 礼来制药 | 详情 | ||
| MT-2990 | MT-2990 | 临床二期 | Mitsubishi Tanabe Pharma Corp | 子宫内膜异位症 | 详情 |
| Itepekimab | REGN-3500; SAR-440340 | 临床三期 | Regeneron Pharmaceuticals Inc, 赛诺菲 | 哮喘, 慢性阻塞性肺疾病, 特应性皮炎 | 详情 |
| Etokimab | ANB-020 | 临床二期 | Anaptysbio Inc | 肺嗜酸粒细胞增多, 哮喘, 鼻窦炎, 花生过敏, 特应性皮炎, 超敏反应 | 详情 |
| Tozorakimab | MEDI-3506 | 临床三期 | Medimmune | 糖尿病肾病, 哮喘, 慢性阻塞性肺疾病, 慢性支气管炎, 特应性皮炎 | 详情 |
| PF-06817024 | PF-06817024 | 临床一期 | 辉瑞 | 鼻疾病, 特应性皮炎 | 详情 |
