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IL-33信息

英文名称:Interleukin-33
中文名称:白细胞介素-33
靶点别称:Nuclear Factor For High Endothelial Venules,DVS27-Related Protein,IL1F11,IL33,Interleukin-1 family member 11,IL-1F11,Interleukin 33,Nuclear Factor From High Endothelial Venules,C9orf26,NF-HEV,Chromosome 9 Open Reading Frame 26 (NF-HEV),Interleukin-1 Family, Member 11,NFEHEV,DVS27,IL-33,NFHEV,Interleukin-33,DKFZp586H0523
上市药物数量:0
临床药物数量:5
最高研发阶段:临床三期

IL-33产品列表

 
评论(4)
IL3-C5245|Cynomolgus IL-33 Protein, His Tag (MALS verified)
  1. 139XXXXXXX9
  2. 1人赞
  3. 该产品用于杂交瘤抗体筛选,需要得到不同种属靶点cross binding的leads,该抗体是通过ELISA进行筛选的,数据显示亲和力良好。
  4. 2021-08-13
IL3-H52H7|Human IL-33 Protein, His Tag
  1. 江苏荃信生物医药有限公司
  2. 5人赞
  3. 项目立项阶段,我们对比了多种品牌的IL-33,最终选择了ACRO的IL-33作为免疫原,并在克隆筛选阶段及后续的方法开发中,作为固定用的试剂,建立的筛选方法稳定可靠。
  4. 2021-05-18
IL3-H52H7|Human IL-33 Protein, His Tag
  1. 187XXXXXXX5
  2. 3人赞
  3. 大包装性价比超级高,当然了价格方面是一个公司最大的考虑因素,也是阻碍科学实验的根本原因,该蛋白在动物免疫领域的优势很明显,蛋白很稳定,质量很好
  4. 2020-04-22
 

IL-33 分子别名

IL33,DV27,C9ORF26,IL1F11,NFHEV,DKFZp586H0523,DVS27,NFEHEV,RP11-575C20.2

IL-33 分子背景

Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.

IL-33 前沿进展

IL-33临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
PF-06817024 PF-06817024 临床一期 辉瑞 鼻疾病, 鼻窦炎, 特应性皮炎 详情
MT-2990 MT-2990 临床二期 Mitsubishi Tanabe Pharma Corp 季节性过敏性鼻炎, 疼痛, 自身免疫疾病, 炎性疾病 详情
Itepekimab REGN-3500; SAR-440340 临床三期 Regeneron Pharmaceuticals Inc, 赛诺菲 哮喘, 慢性阻塞性肺疾病, 特应性皮炎 详情
Torudokimab LY-3375880 临床二期 礼来制药 特应性皮炎 详情
Etokimab ANB-020 临床二期 Anaptysbio 肺嗜酸粒细胞增多, 鼻窦炎, 哮喘, 花生过敏, 特应性皮炎, 超敏反应 详情

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