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IL-1RL1信息

英文名称:Interleukin-1 receptor-like 1
中文名称:白介素1受体样蛋白1
靶点别称:ST2,IL1RL1,Protein ST2,DER4,T1,Interleukin 1 Receptor Like 1,Homolog Of Mouse Growth Stimulation-Expressed,Interleukin 1 Receptor-Related Protein,Growth Stimulation-Expressed,FIT-1,IL33R,ST2L,ST2V,Interleukin-1 Receptor-Like 1 Protein,EC:3.2.2.6,Interleukin-1 Receptor-Like 1
上市药物数量:0
临床药物数量:5
最高研发阶段:申请上市

IL-1RL1 分子别名

IL1RL1,DER4,FIT-1,IL33R,ST2,ST2L,ST2V,T1

IL-1RL1 分子背景

Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.

IL-1RL1 前沿进展

IL-1RL1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Recombinant humanized anti-ST2 monoclonal antibody 9MW1911; 9-MW1911; 9MW-1911; 9-MW-1911 临床一期 迈威(上海)生物科技股份有限公司 哮喘, 慢性阻塞性肺疾病, 特应性皮炎 详情
Astegolimab AMG-282; RG-6149; RO-7187807 临床二期 安进, 罗氏 新型冠状病毒肺炎, 哮喘, 鼻窦炎, 慢性阻塞性肺疾病, 特应性皮炎 详情
Tozorakimab MEDI-3506 临床三期 Medimmune 哮喘, 糖尿病肾病, 慢性阻塞性肺疾病, 慢性支气管炎, 特应性皮炎 详情

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