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 > 【IL-1RL1】重组蛋白信息

IL-1RL1信息

英文名称:Interleukin-1 receptor-like 1
中文名称:白介素1受体样蛋白1
靶点别称:ST2,IL1RL1,Protein ST2,DER4,T1,Interleukin 1 Receptor Like 1,Homolog Of Mouse Growth Stimulation-Expressed,Interleukin 1 Receptor-Related Protein,Growth Stimulation-Expressed,FIT-1,IL33R,ST2L,ST2V,Interleukin-1 Receptor-Like 1 Protein,EC:3.2.2.6,Interleuk
上市药物数量:0
临床药物数量:4
最高研发阶段:临床三期

IL-1RL1产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
IL1-H5229
Human
Human IL-1RL1 / ST2 Protein, His Tag
IL1-H5250
Human
Human IL1RL1 /ST2 Protein, With C-Fc Tag
 
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IL-1RL1 分子别名

IL1RL1,DER4,FIT-1,IL33R,ST2,ST2L,ST2V,T1

IL-1RL1 分子背景

Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.

IL-1RL1 参考文献

IL-1RL1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AMG-282 AMG-282; RG-6149; RO-7187807 临床二期 罗氏, 安进 新型冠状病毒肺炎, 鼻窦炎, 哮喘, 特应性皮炎 详情
CNTO-7160 CNTO-7160; GSK-3772847 临床二期 杨森 哮喘, 特应性皮炎 详情
Anti-IL-33 mAb (Regeneron Pharmaceuticals/Sanofi) REGN-3500; SAR-440340 临床三期 Regeneron Pharmaceuticals Inc, 赛诺菲 哮喘, 慢性阻塞性肺疾病, 特应性皮炎 详情
MEDI-3506 MEDI-3506 临床二期 Medimmune 哮喘, 糖尿病肾病, 慢性阻塞性肺疾病, 特应性皮炎, 慢性支气管炎 详情

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