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IL-17F信息

英文名称:Interleukin-17F
中文名称:白介素-17F
靶点别称:Cytokine ML-1,Interleukin-17F,IL17F,Interleukin 17F,IL-17F,CANDF6,ML-1,ML1
上市药物数量:0
临床药物数量:5
最高研发阶段:临床二期

IL-17F 分子别名

IL-17F,Interleukin-17F,Cytokine ML-1

IL-17F 分子背景

Interleukin-17F (IL17F) is also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family. There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24). IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6).

IL-17F 前沿进展

IL-17F临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
HY-1770 HY1770; HT-17; HT17; HY-1770 临床一期 苏州沪云新药研发股份有限公司 斑块银屑病 详情
BAT-2306 临床一期 百奥泰生物制药股份有限公司 自身免疫疾病, 银屑病, 斑块银屑病 详情
Recombinant human IL-17A/F humanized antibody (Livzon Pharmaceutical Group) LZM-012; LZM012 临床二期 丽珠医药集团股份有限公司, 北京鑫康合生物医药科技有限公司 强直性脊柱炎, 银屑病, 斑块银屑病 详情
DMT-310 DMT-310 临床二期 Dermata 寻常痤疮, 酒渣鼻 详情
Sonelokimab M-1095; ALX-0761; MSB-0010841 临床二期 Ablynx 银屑病 详情

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