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 > 【IL-13 R alpha 2】重组蛋白信息

IL-13 R alpha 2信息

英文名称:Interleukin-13 receptor subunit alpha-2
靶点别称:IL-13RA2,IL-13R-alpha-2,Interleukin-13-binding protein,IL13RA2,Interleukin 13 Receptor Subunit Alpha 2,Interleukin 13 Receptor, Alpha 2,IL-13 Receptor Subunit Alpha-2,Cancer/Testis Antigen 19,IL-13R Subunit Alpha-2,Interleukin-13 Receptor Subunit Alpha-2,

IL-13 R alpha 2 分子别名

Daines MO., et al., 2006, J. Immunol., 176: 7495-7501.

IL-13 R alpha 2 分子背景

Interleukin-13 receptor subunit alpha-2 is also known as IL13Rα2, IL13Ra2 cluster of differentiation 213A2, CD213A2, CT19, IL-13R, IL13BP, and is a membrane bound protein that in humans is encoded by the IL13RA2 gene. IL13Rα2 is closely related to IL13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL13 and IL4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13. IL13Rα2 is a component of the cell surface receptors, however, the majority exists in intracellular pools and in soluble form, and thus plays an opposite role as a potent IL13 antagonist compared with IL13Rα1. It also functions as an inhibitor of IL4-dependent pathway probably through the physical interaction between the short intracellular domain of and cytoplasmic domain of IL13Rα2 and the IL4Rα chain. In spite of the failed STAT signaling function, IL13Rα2 dose induce TGF-beta production and fibrosis. Additionally, IL13Rα2has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme.

IL-13 R alpha 2 参考文献

IL-13 R alpha 2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
IL13Ralpha2 CAR-T cell therapy (Jonsson Comprehensive Cancer Center) 临床一期 Uclas Jonsson Comprehensive Cancer Center 黑色素瘤 详情
MB-101 (Mustang Bio) MB-101 临床一期 希望之城国家医疗中心, Mustang Bio 胶质母细胞瘤 详情