IL-12B 靶点蛋白|抗体药物|临床药物信息

IL-12B信息

英文名称：Interleukin-12 subunit beta
中文名称：白细胞介素-12β亚基
靶点别称：IL-12B，NK cell stimulatory factor chain 2，IL12B，Interleukin 12B，Interleukin 12B (Natural Killer Cell Stimulatory Factor 2， Cytotoxic Lymphocyte Maturation Factor 2， P40)，Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit，Interleukin-12 Beta Chain，Interleukin 12， P40，IL12， Subunit P40，CLMF P40，NKSF2，Cytotoxic Lymphocyte Maturation Factor 2， P40，Interleukin-12 Subunit Beta，CLMF2，IMD28，IMD29，CLMF，NKSF，Interleukin-12 Subunit p40，Natural Killer Cell Stimulatory Factor， 40 KD Subunit，IL-12 Subunit

上市药物数量：1
临床药物数量：3
最高研发阶段：批准上市

IL-12B产品列表

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在线 (4)

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货号	物种	产品描述
EP-156	Human	IL-12B : IL-12RB1 [Biotinylated] Inhibitor Screening ELISA Kit
NK2-H5258	Human	Human IL-12B / NKSF2 / p40 Protein, Fc Tag
NK2-H52H7	Human	Human IL-12B / NKSF2 / p40 Protein, His Tag
NK2-M82E5	Mouse	Biotinylated Mouse IL-12B / NKSF2 / p40 Protein, His,Avitag™ (MALS verified)

IL-12B分子别名

IL12B,CLMF,CLMF2,NKSF,NKSF2,p40

IL-12B分子背景

Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.
Interleukin-12 subunit beta (IL12B) also known as NKSF2, CLMF2 and P40. Interleukin-12 subunit beta has been shown to interact with IL23. A large excess of monomeric IL12B is also secreted by the cells producing IL12, and exhibits no demonstrable biological activity. Overexpression of IL12B gene has been shown to be associated with the pathogenesis of multiple sclerosis. In addition, studies have revealed that the promoter polymorphism of this gene is implicated in the severity of atopic and non-atopic asthma in children.

IL-12B上市药物信息

英文名称	中文名称	研发代码	研发阶段	公司	最早商品名	最早批准国家	最早适应症	最早批准公司	最早批准日期	适应症	临床试验
Ustekinumab	乌司奴单抗	CNTO-1275; C-340; AVT-04	批准上市	杨森	喜达诺, Stelara	United States	斑块银屑病	Janssen Biotech Inc	2009-09-25	多发性硬化, 特应性皮炎, 斑块银屑病, 克罗恩病, 普通可变性免疫缺陷, 葡萄膜炎, 化脓性汗腺炎, 银屑病关节炎, 溃疡性结肠炎, 系统性红斑狼疮, 大动脉炎, 银屑病, 胆汁性肝硬化, 幼年型类风湿性关节炎, 强直性脊柱炎, 鳞癣, Sjtoegren综合征, 隐窝炎, 白细胞黏附缺陷症Ⅰ型, 皮肌炎, 炎症性肠疾病, 多发性肌炎, 一型糖尿病	详情

IL-12B临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
SAR-441000	SAR441000; SAR-441000; BNT-131	临床一期	Biontech Se, 赛诺菲	转移癌	详情
Ebdarokimab	AK-101	临床三期		银屑病, 溃疡性结肠炎, 银屑病关节炎, 克罗恩病, 斑块银屑病	详情
Ustekinumab biosimilar(Amgen)	ABP-654	临床三期	安进	实体瘤, 银屑病	详情

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IL-12B