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IL-12B信息

英文名称:Interleukin-12 subunit beta
中文名称:白细胞介素-12β亚基
靶点别称:IL-12B,NK cell stimulatory factor chain 2,IL12B,Interleukin 12B,Interleukin 12B (Natural Killer Cell Stimulatory Factor 2, Cytotoxic Lymphocyte Maturation Factor 2, P40),Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit,Interleukin-12 Beta Chain,Interleukin 12, P40,IL12, Subunit P40,CLMF P40,NKSF2,Cytotoxic Lymphocyte Maturation Factor 2, P40,Interleukin-12 Subunit Beta,CLMF2,IMD28,IMD29,CLMF,NKSF,Interleukin-12 Subunit p40,Natural Killer Cell Stimulatory Factor, 40 KD Subunit,IL-12 Subunit
上市药物数量:0
临床药物数量:1
最高研发阶段:批准上市

IL-12B 分子别名

IL12B,CLMF,CLMF2,NKSF,NKSF2,p40

IL-12B 分子背景

Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.Interleukin-12 subunit beta (IL12B) also known as NKSF2, CLMF2 and P40. Interleukin-12 subunit beta has been shown to interact with IL23. A large excess of monomeric IL12B is also secreted by the cells producing IL12, and exhibits no demonstrable biological activity. Overexpression of IL12B gene has been shown to be associated with the pathogenesis of multiple sclerosis. In addition, studies have revealed that the promoter polymorphism of this gene is implicated in the severity of atopic and non-atopic asthma in children.

IL-12B 前沿进展

IL-12B临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Ustekinumab biosimilar(Amgen) ABP-654 安进 详情
SAR-441000 SAR441000; SAR-441000; BNT-131 Biontech Se, 赛诺菲 详情
Ebdarokimab AK-101 临床三期 中山康方生物医药有限公司 银屑病, 溃疡性结肠炎, 银屑病关节炎, 克罗恩病, 斑块银屑病 详情

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