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IL-12B信息

英文名称:Interleukin-12 subunit beta
中文名称:白细胞介素-12β亚基
靶点别称:IL-12B,NK cell stimulatory factor chain 2,IL12B,Interleukin 12B,Interleukin 12B (Natural Killer Cell Stimulatory Factor 2, Cytotoxic Lymphocyte Maturation Factor 2, P40),Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit,Interleukin-12 Beta Chain,Interleukin 12, P40,IL12, Subunit P40,CLMF P40,NKSF2,Cytotoxic Lymphocyte Maturation Factor 2, P40,Interleukin-12 Subunit Beta,CLMF2,IMD28,IMD29,CLMF,NKSF,Interleukin-12 Subunit p40,Natural Killer Cell Stimulatory Factor, 40 KD Subunit,IL-12 Subunit
上市药物数量:1
临床药物数量:3
最高研发阶段:批准上市

IL-12B分子别名

IL12B,CLMF,CLMF2,NKSF,NKSF2,p40

IL-12B分子背景

Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.
Interleukin-12 subunit beta (IL12B) also known as NKSF2, CLMF2 and P40. Interleukin-12 subunit beta has been shown to interact with IL23. A large excess of monomeric IL12B is also secreted by the cells producing IL12, and exhibits no demonstrable biological activity. Overexpression of IL12B gene has been shown to be associated with the pathogenesis of multiple sclerosis. In addition, studies have revealed that the promoter polymorphism of this gene is implicated in the severity of atopic and non-atopic asthma in children.

IL-12B上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Ustekinumab 乌司奴单抗 CNTO-1275; C-340; AVT-04 批准上市 杨森 喜达诺, Stelara United States 斑块银屑病 Janssen Biotech Inc 2009-09-25 多发性硬化, 特应性皮炎, 斑块银屑病, 克罗恩病, 普通可变性免疫缺陷, 葡萄膜炎, 化脓性汗腺炎, 银屑病关节炎, 溃疡性结肠炎, 系统性红斑狼疮, 大动脉炎, 银屑病, 胆汁性肝硬化, 幼年型类风湿性关节炎, 强直性脊柱炎, 鳞癣, Sjtoegren综合征, 隐窝炎, 白细胞黏附缺陷症Ⅰ型, 皮肌炎, 炎症性肠疾病, 多发性肌炎, 一型糖尿病 详情

IL-12B临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
SAR-441000 SAR441000; SAR-441000; BNT-131 临床一期 Biontech Se, 赛诺菲 转移癌 详情
Ebdarokimab AK-101 临床三期 银屑病, 溃疡性结肠炎, 银屑病关节炎, 克罗恩病, 斑块银屑病 详情
Ustekinumab biosimilar(Amgen) ABP-654 临床三期 安进 实体瘤, 银屑病 详情

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