IL-12A 靶点蛋白|抗体药物|临床药物信息

IL-12A信息

英文名称：Interleukin-12 subunit alpha
中文名称：白介素12α亚基
靶点别称：IL-12A，Cytotoxic lymphocyte maturation factor 35 kDa subunit，CLMF p35，IL-12 subunit p35，NK cell stimulatory factor chain 1，NKSF1

上市药物数量：0
临床药物数量：1
最高研发阶段：临床一期

IL-12A产品列表

筛选结果

产品库

在线 (1)

物种

Human (1)

标签

Fc Tag (1)

属性

Protein (1)

标记

Unconjugated (1)

货号	物种	产品描述	蛋白结构	纯度	活性
NK1-H5252	Human	Human IL12A /NKSF1 Protein,C-Fc Tag,HEK293 expressed

IL-12A 分子别名

IL12A,CLMF,IL-12A,NFSK,NKSF1,P35

IL-12A 分子背景

Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels. Interleukin-12 subunit alpha (IL12A) also known as NKSF1, CLMF1 and P35, IL12A shows significant sequence similarity to IL-6, G-CSF, and exerts biological activities only when the IL12B is co-expressed. IL12B deficient mice are resistant to the induction of experimental chronic inflammatory diseases whereas IL12A knock-out mice develop more severe forms, suggesting opposite functions of the two subunits in the outcome of chronic inflammatory diseases.

IL-12A 前沿进展

IL-12A临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
SAR-441000	SAR441000; SAR-441000; BNT-131	临床一期	Biontech Se, 赛诺菲	转移癌	详情

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IL-12A