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IL-10信息

英文名称:Interleukin-10
中文名称:白细胞介素-10
靶点别称:Interleukin 10,IL-10,IL10,CSIF,Cytokine Synthesis Inhibitory Factor,T-Cell Growth Inhibitory Factor,Interleukin-10,GVHDS,IL10A,TGIF
上市药物数量:0
临床药物数量:7
最高研发阶段:临床二期

Licensing 项目合作

项目名称 适应症 项目阶段 合作需求
BIA202204 脓毒血症,细胞因子释放综合征(CRS),噬血细胞性淋巴组织细胞增多症(HLH) CMC进行中 寻求项目转让或者合作开发

IL-10产品列表

 
评论(1)
IL0-M4248|Mouse IL-10 Protein, His Tag
  1. 188XXXXXXX7
  2. 4人赞
  3. 实验要开始发现IL-10没有,但是急用,本来一直都在用R&D的产品,但是货到的太慢了,然后平时项目组做SPR的话经常会用Acro的蛋白,到货较快。于是我就抱着试试看的心态购买了Acro的IL-10,到货以后是真香,不仅价格美丽,到货快,在效果上并不比R&D差,强推!
  4. 2022-06-15
 

IL-10 分子别名

CSIF,IL-10,IL10A,TGIF,B-TCGF,GVHDS,MGC126450,MGC126451,RP11-262N9.1,Interleukin-10

IL-10 分子背景

Interleukin-10 (IL-10) is also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. Mature human IL-10 shares 72% - 86% amino acid sequence identity with bovine, canine, equine, feline, mouse, ovine, porcine, and rat IL-10. Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and regulatory T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production. Knockout studies suggested the function of Interleukin-10 / IL-10 as an essential immunoregulator in the intestinal tract. Patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant interleukin-10, showing the importance of interleukin-10 for counteracting excessive immunity in the human body.

IL-10 前沿进展

IL-10临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Recombinant anti-InE monoclonal antibody CmAb-(IL10)2 临床一期 苏州丁孚靶点生物技术有限公司 实体瘤 详情
BT-063 BT-063 Biotest 详情
WP-1303 (worgpharma) M-2736; WP-1303; ATX-MS-1467; ATX-MS-01; MSC-2358825A 临床二期 Apitope Technology 详情
KLS-2031 KLS-2031 临床二期 Kolon Life Science 神经根病 详情

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