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IGF-I信息

英文名称:Insulin-like growth factor I
中文名称:胰岛素样生长因子-I
靶点别称:IGF-I,Insulin-Like Growth Factor IB,Insulin-Like Growth Factor I,Somatomedin C,IGFI,IGF1A,IGF,IBP1,MGF,Mechano growth factor,IGF1,Insulin Like Growth Factor 1,Insulin-Like Growth Factor 1 (Somatomedin C),Somatomedin-C
上市药物数量:0
临床药物数量:2
最高研发阶段:临床前

IGF-I产品列表

 
评论(1)
IG1-H5245|Human IGF-I Protein, His Tag (SPR verified)
  1. 187XXXXXXX9
  2. 1人赞
  3. 目前我们所用来做SPR和抗原检测,之前买的蛋白溶解后会析出,或者吸附到EP管管壁上,损失很大,含量也会达不到要求,抗原加标的时候很麻烦,但是在这边购买的蛋白基本没有这些副作用,很好用,省了我们很多时间
  4. >
  5. 2022-08-02
 

IGF-I 分子别名

IGF-I,IGF1A,somatomedin C,MGF

IGF-I 分子背景

Insulin-like growth factor 1 (IGF-1) is also known as somatomedin C, IGF1A, IGFI, sulfation factor, and is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. IGF-1 binds to at least two cell surface receptors: the Insulin-like growth factor 1 receptor, abbreviated as "IGF1R", and the insulin receptor. The IGF-1 receptor seems to be the "physiologic" receptor - it binds IGF-1 at significantly higher affinity than the IGF-1 that is bound to the insulin receptor. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. Its primary action is mediated by binding to its specific receptor IGF1R, present on many cell types in many tissues. Binding to the IGF1R, a receptor tyrosine kinase, initiates intracellular signaling; IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and proliferation, and a potent inhibitor of programmed cell death. Insulin-like growth factor 1 has been shown to bind and interact with all the IGF-1 Binding Proteins (IGFBPs), of which there are six (IGFBP1-6). Specific references are provided for interactions with IGFBP3, IGFBP4 and IGFBP7.

IGF-I 前沿进展

IGF-I临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Dusigitumab MEDI-573 Medimmune Llc 详情
Xentuzumab BI-836845 勃林格殷格翰 详情
ACT-01 ACT-01; OCS-05; BN-201; G-79 Promius 详情

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