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IDH1信息

英文名称:Isocitrate dehydrogenase [NADP] cytoplasmic
中文名称:细胞质异柠檬酸脱氢酶[NADP]
靶点别称
上市药物数量:1
临床药物数量:9
最高研发阶段:批准上市

IDH1产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
ID1-H51H6
Human
Human IDH1 Protein, His Tag (active enzyme, MALS verified)
 
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IDH1 分子别名

IDH1,PICD,IDP

IDH1 分子背景

The IDH enzymes catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (α-KG), producing nicotinamide adenine dinucleotide phosphate (NADPH) in the process via the citric acid cycle. Eukaryotic cells express two distinct classes of IDHs that utilize either NAD or NADP as their cofactors and serve diverse biological functions. NAD-dependent IDH is localized to the mitochondrial matrix and is well known for its central role for energy production in the Krebs cycle. NADP-dependent IDHs are primarily located either in mitochondria or cytoplasm . Each NADP-dependent isozyme is a homodimer. Mutations of Arg132 of human IDH1 result in a reduced ability of the enzyme to convert isocitrate to alpha ‑ketoglutarate, but the enzyme acquires the ability to generate 2-hydroxyglutarate (2HG) from alpha‑ketoglutarate, 2-HG is elevated in several tumor types, including a subset of AMLs.

IDH1 前沿进展

IDH1上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验

IDH1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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