ICOS 靶点蛋白|抗体药物|临床药物信息

ICOS信息

英文名称：Inducible T-cell costimulator
中文名称：诱导T细胞共刺激分子
靶点别称：Activation-inducible lymphocyte immunomediatory molecule，Inducible T-cell costimulator，ICOS，CD278，AILIM，Inducible T Cell Costimulator，Inducible T-Cell Co-Stimulator，Inducible Costimulator，CD278 Antigen，CVID1，Inducible T-Cell Co-Stimulator Protein

上市药物数量：0
临床药物数量：7
最高研发阶段：临床三期

ICOS产品列表

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在线 (6)

物种

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Protein (6)

标记

货号	物种	产品描述
ICS-H82E5	Human	Biotinylated Human ICOS / CD278 (C136S, C137S) Protein, His,Avitag™ (recommended for biopanning)
ICS-H5258	Human	Human ICOS / CD278 Protein, Fc Tag
ICS-M52H8	Mouse	Mouse ICOS / CD278 (C137S, C138S) Protein, His Tag
ICS-M5259	Mouse	Mouse ICOS / CD278 (C137S, C138S) Protein, Fc Tag
ICS-H52H9	Human	Human ICOS / CD278 (C136S, C137S) Protein, His Tag (MALS verified)
ICS-R52H9	Rat	Rat ICOS / CD278 (C137S, C138S) Protein, His Tag

ICOS 分子别名

ICOS,CD278,AILIM,Inducible T-cell costimulator

ICOS 分子背景

Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

ICOS 前沿进展

ICOS临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Izuralimab	XmAb-23104; XmAb-104	临床一期	Xencor Inc	鼻咽癌, 宫颈癌, 黑色素瘤, 非小细胞肺癌, 肝细胞癌, 子宫内膜癌, 结直肠癌, 肉瘤, 乳腺癌, 实体瘤, 小细胞肺癌, 胰腺癌, 尿路上皮癌, 肿瘤, 食道癌, 头颈部鳞状细胞癌, 肾细胞癌, 胃癌	详情
Feladilimab	GSK-609; GSK-3359609	临床三期	葛兰素史克	头颈癌, 实体瘤, 头颈部鳞状细胞癌, 肿瘤, 多发性骨髓瘤	详情
Alomfilimab	KY-1044	临床二期	Kymab Ltd	头颈部鳞状细胞癌, 肾细胞癌, 食道癌, 胃癌, 三阴性乳腺癌, 肿瘤, 胰腺癌, 黑色素瘤, 肝细胞癌, 非小细胞肺癌, 宫颈癌, 转移癌	详情
Vopratelimab	JTX-2011	临床二期	Jounce Therapeutics Inc	肿瘤, 非小细胞肺癌	详情
MEDI-570		临床一期	日本烟草（香港）有限公司	滤泡中心淋巴瘤, 系统性红斑狼疮, T-细胞淋巴瘤, 皮肤T细胞淋巴瘤, 非霍奇金淋巴瘤, 蕈样真菌病	详情
Anti-ICOS (Bristol Myers Squibb)	BMS-986226	临床一期	百时美施贵宝	肿瘤	详情
Acazicolcept	ALPN-101	临床二期	Alpine Immune Sciences Inc, 艾伯维	移植物抗宿主病, 自身免疫疾病, 系统性红斑狼疮, X-连锁淋巴增生症, 炎性疾病	详情

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