GITR 靶点蛋白|抗体药物|临床药物信息

GITR信息

英文名称：Glucocorticoid-induced tumor necrosis factor receptor-related protein
中文名称：糖皮质激素诱导的肿瘤坏死因子受体相关蛋白
靶点别称：TNFRSF18，TNF Receptor Superfamily Activation-Inducible Protein，ENERGEN，GITR-D，Tumor Necrosis Factor Receptor Superfamily Member 18，CD357 Antigen，Activation-Inducible TNFR Family Receptor，AITR，CD357，GITR，Glucocorticoid-Induced TNFR-Related Protein，Tumor Necrosis Factor Receptor Superfamily， Member 18，TNF Receptor Superfamily Member 18

上市药物数量：0
临床药物数量：4
最高研发阶段：临床二期

GITR产品列表

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在线 (10)

物种

标签

属性

Protein (10)

标记

货号	物种	产品描述
GIR-H5228	Human	Human GITR / TNFRSF18 Protein, His Tag
GIR-H5254	Human	Human GITR / TNFRSF18 Protein, Fc Tag
GIR-C52H6	Canine	Canine GITR / TNFRSF18 Protein, His Tag
GIR-M5220	Mouse	Mouse GITR / TNFRSF18 Protein, His Tag
GIR-R5222	Rat	Rat GITR / TNFRSF18 Protein, His Tag
GIR-R5253	Rat	Rat GITR / TNFRSF18 Protein, Fc Tag
GIR-C5255	Rhesus macaque	Rhesus macaque GITR / TNFRSF18 Protein, Fc Tag
GIR-H525a	Human	Human GITR / TNFRSF18 Protein, Mouse IgG2a Fc Tag, low endotoxin
GIR-H82F7	Human	Biotinylated Human GITR / TNFRSF18 Protein, Fc,Avitag™
GIR-H82E1	Human	Biotinylated Human GITR / TNFRSF18 Protein, His,Avitag™ (MALS verified)

GIR-H5228|Human GITR / TNFRSF18 Protein, His Tag (MALS verified)

151XXXXXXX3

4人赞

使用Acro的产品很久了，不管是产品还是技术，每次都是有问题及时解决。用过的GITR蛋白，做过SPR实验，6个浓度梯度做，拟合曲线也很不错，数据也是达到我的预期，希望以后还是合作愉快。
2019-09-27

GIR-H5228|Human GITR / TNFRSF18 Protein, His Tag (MALS verified)

181XXXXXXX2

0人赞

购买该产品主要用于小鼠免疫和体外功能实验。在小鼠免疫方面，二免时使用猴GITR蛋白，流式检测效价时小鼠血清与猴GITR有比较好的结合，能达到10万效价。体外实验主要是进行抗体的亲和力筛选，蛋白活性很好，抗体分子与该蛋白有比较好的结合/解离曲线。后续会一直使用此款产品。
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2023-03-09

GITR 分子别名

AITR,GITR,TNFRSF18,CD357

GITR 分子背景

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

GITR 前沿进展

GITR临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Anti-GITR antibody (BMS)		临床一期	百时美施贵宝	肿瘤	详情
Ragifilimab	INCAGN-1876; INCAGN-01876; AGEN-1876; CM-701	临床二期	安帝君斯公司, 路德维格癌症研究所	肿瘤, 转移癌	详情
REGN-6569	REGN6569; REGN-6569	临床一期	Regeneron Pharmaceuticals Inc	头颈部鳞状细胞癌	详情

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GITR