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GITR信息

英文名称:Glucocorticoid-induced tumor necrosis factor receptor-related protein
中文名称:糖皮质激素诱导的肿瘤坏死因子受体相关蛋白
靶点别称:GITR,Glucocorticoid-Induced TNFR-Related Protein,Tumor Necrosis Factor Receptor Superfamily, Member 18,TNF Receptor Superfamily Member 18,ENERGEN,GITR-D,TNFRSF18,TNF Receptor Superfamily Activation-Inducible Protein,AITR,CD357,Tumor Necrosis Factor Recept
上市药物数量:0
临床药物数量:8
最高研发阶段:临床二期

GITR产品列表

 
评论(1)
GIR-H5228|Human GITR / TNFRSF18 Protein, His Tag (MALS verified)
  1. 151XXXXXXX3
  2. 3人赞
  3. 使用Acro的产品很久了,不管是产品还是技术,每次都是有问题及时解决。用过的GITR蛋白,做过SPR实验,6个浓度梯度做,拟合曲线也很不错,数据也是达到我的预期,希望以后还是合作愉快。
  4. 2019-09-27
 

GITR Molecule Synonym Name

AITR,GITR,TNFRSF18,CD357

GITR 分子背景

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

GITR 参考文献

GITR临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
ASP-1951 PTZ-522; ASP-1951 临床一期 Potenza Therapeutics 肿瘤 详情
TRX-518 TRX-518 临床二期 Tolerx 卵巢癌, 乳腺癌, 前列腺癌 详情
BMS-986156 BMS-986156 临床二期 百时美施贵宝 肿瘤 详情
MK-4166 MK-4166 临床一期 Merck & Co Inc 胶质母细胞瘤 详情
Anti-GITR antibody (BMS) 临床一期 百时美施贵宝 肿瘤
GWN-323 GWN-323 临床一期 诺华制药 淋巴瘤 详情
INCAGN-1876 INCAGN-1876; INCAGN-01876 临床二期 Agenus Inc, 路德维格癌症研究所 转移癌 详情

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