GITR 靶点蛋白|抗体药物|临床药物信息

GITR信息

英文名称：Glucocorticoid-induced tumor necrosis factor receptor-related protein
中文名称：糖皮质激素诱导的肿瘤坏死因子受体相关蛋白
靶点别称：GITR，Glucocorticoid-Induced TNFR-Related Protein，Tumor Necrosis Factor Receptor Superfamily， Member 18，TNF Receptor Superfamily Member 18，ENERGEN，GITR-D，TNFRSF18，TNF Receptor Superfamily Activation-Inducible Protein，AITR，CD357，Tumor Necrosis Factor Recept

上市药物数量：0
临床药物数量：8
最高研发阶段：临床二期

GITR产品列表

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产品库

在线 (10)

物种

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属性

Protein (10)

标记

货号	物种	产品描述
GIR-H5228	Human	Human GITR / TNFRSF18 Protein, His Tag
GIR-M5220	Mouse	Mouse GITR / TNFRSF18 Protein, His Tag
GIR-R5222	Rat	Rat GITR / TNFRSF18 Protein, His Tag
GIR-R5253	Rat	Rat GITR / TNFRSF18 Protein, Fc Tag
GIR-C5255	Rhesus macaque	Rhesus macaque GITR / TNFRSF18 Protein, Fc Tag
GIR-H5254	Human	Human GITR / TNFRSF18 Protein, Fc Tag
GIR-H525a	Human	Human GITR / TNFRSF18 Protein, Mouse IgG2a Fc Tag, low endotoxin
GIR-H82F7	Human	Biotinylated Human GITR / TNFRSF18 Protein, Fc,Avitag
GIR-C52H6	Canine	Canine GITR / TNFRSF18 Protein, His Tag
GIR-H82E1	Human	Biotinylated Human GITR / TNFRSF18 Protein, His,Avitag™ (MALS verified)

GIR-H5228|Human GITR / TNFRSF18 Protein, His Tag (MALS verified)

151XXXXXXX3

3人赞

使用Acro的产品很久了，不管是产品还是技术，每次都是有问题及时解决。用过的GITR蛋白，做过SPR实验，6个浓度梯度做，拟合曲线也很不错，数据也是达到我的预期，希望以后还是合作愉快。
2019-09-27

GITR Molecule Synonym Name

AITR,GITR,TNFRSF18,CD357

GITR 分子背景

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

GITR 参考文献

GITR临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
ASP-1951	PTZ-522; ASP-1951	临床一期	Potenza Therapeutics	肿瘤	详情
TRX-518	TRX-518	临床二期	Tolerx	卵巢癌, 乳腺癌, 前列腺癌	详情
BMS-986156	BMS-986156	临床二期	百时美施贵宝	肿瘤	详情
MK-4166	MK-4166	临床一期	Merck & Co Inc	胶质母细胞瘤	详情
Anti-GITR antibody (BMS)		临床一期	百时美施贵宝	肿瘤
GWN-323	GWN-323	临床一期	诺华制药	淋巴瘤	详情
INCAGN-1876	INCAGN-1876; INCAGN-01876	临床二期	Agenus Inc, 路德维格癌症研究所	转移癌	详情

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GITR 重组蛋白