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Furin信息

英文名称:Furin
中文名称:弗林蛋白酶
靶点别称:Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE
上市药物数量:0
临床药物数量:1
最高研发阶段:临床三期

Furin产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
FUN-H52H3
Human
Human Furin / PCSK3 Protein, His Tag
 
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Furin 分子别名

FURIN,FUR,PACE,PCSK3,SPC1

Furin 分子背景

Furin is also known as paired basic Amino acid Cleaving Enzyme (PACE), is an enzyme which belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. The expression of furin in T-cells is required for maintenance of peripheral immune tolerance. Furin cleaves proteins just downstream of a basic amino acid target sequence (canonically, Arg-X-(Arg/Lys) -Arg'). PACE is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. In addition to processing cellular precursor proteins, furin is also utilized by a number of pathogens. For example, the envelope proteins of viruses such as HIV, influenza and dengue fever viruses must be cleaved by furin or furin-like proteases to become fully functional. PACE also play a role in tumor progression.

Furin 前沿进展

Furin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Bi-shRNAfurin and GMCSF augmented autologous tumor cell immunotherapy (Gradalis/Mary Crowley) IND-14205 临床三期 Gradalis 卵巢癌, 肝癌, 结肠癌, 乳腺癌, 尤因肉瘤, 腹膜癌, 女性生殖系统癌症, 子宫肿瘤, 输卵管癌, 子宫内膜癌, 肺癌, 宫颈癌, 非小细胞肺癌, 黑色素瘤 详情

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