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FOLR2信息

英文名称:Folate receptor beta
中文名称:叶酸受体β
靶点别称:FOLR1,FRbeta,Folate Receptor Alpha,FBP,Placental folate-binding protein,Folate receptor, fetal/placental,FOLR2,Folate receptor beta,Folate Receptor 2 (Fetal),Folate-Binding Protein, Fetal/Placental,BETA-HFR,FBP/PL-1,FR-Beta,FR-P3,Folate Receptor 2,FRβ
上市药物数量:0
临床药物数量:2
最高研发阶段:临床三期

FOLR2产品列表

ACRO质量管理体系
 
评论(6)
FO2-H5223|Human FOLR2 Protein, His Tag
  1. 151XXXXXXX5
  2. 0人赞
  3. 一个新的试验不得不需要尝试新的抗体试剂,知道了这个品牌后,就毫不犹豫的下单了,疫情期间发货速度也快,一点没有耽误试验,经过多次的验证证明了这个试剂的稳定与可靠性,目前已经成为我们实验室的首选试剂
  4. 2023-01-17
FO2-H5223|Human FOLR2 Protein, His Tag
  1. 188XXXXXXX0
  2. 0人赞
  3. 又一次购买他家的试剂,现在如有购买意向,第一时间想到的就是这家公司。抗体试剂价格适中、产品稳定,售后服务体系完善,实验中遇到的问题都热情耐心的回答!值得信赖的好公司
  4. 2023-01-24
FO2-H5223|Human FOLR2 Protein, His Tag
  1. 131XXXXXXX6
  2. 0人赞
  3. 购买该产品主要用于抗体的筛选鉴定,主要应用于ELISA试验,试验结果满足预期,有很好的区分度,产品一如既往的高品质,服务态度也很好,售后和技术支持响应很快。
  4. 2023-01-17
 

FOLR2分子别名

FOLR2,BETA-HFR,FBP,PL-1,FR-BETA,FR-P3,FBP

FOLR2分子背景

Folate receptor beta is also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family. and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.

FOLR2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Arfolitixorin ISO-901; 6R-MTHF 临床三期 Isofol Medical Ab 直肠癌, 结肠癌, 骨肉瘤, 结直肠癌 详情
UB-TT170 UB-TT170; UB-TT-170; UB_TT170; UB_TT-170 临床一期 Umoja BioPharma Inc 骨肉瘤 详情

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