Recombinant Proteins iso9001 ISO13485
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FKBP12信息

英文名称:FK506-binding protein 1A
中文名称:FK506结合蛋白-1A
靶点别称:Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A,FK506-Binding Protein, T-Cell, 12-KD,FK506-Binding Protein 1A (12kD),Protein Kinase C Inhibitor 2,FK506-Binding Protein 12,FK506 Binding Protein12,FK506-Binding Protein 1,FKBP12-Exip3,Calstabin 1,PPIASE,PKC12,PKC
上市药物数量:1
临床药物数量:1
最高研发阶段:批准上市

FKBP12产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
FKA-H5122
Human
Human FKBP12 / FKBP1A Protein, His Tag
 
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FKBP12 分子别名

FKBP1A,FKBP1,Calstabin-1,FKBP12,Rotamase,PKC12,PPIASE

FKBP12 分子背景

Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.

FKBP12 参考文献

FKBP12上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Tacrolimus Hydrate 他克莫司水合物 L-679934; FK-506MR; FK-506E; FK-506; MR-4; RTU-007; FR-900506; LCP-Tacro 批准上市 Astellas Pharma Inc Protopy, Graceptor (as hydrate), Advagraf, Envarsus, Modigraf, Astagraf XL, Protopic, TacroBell, Prograf (as hydrate), Hecoria (as hydrate), Hexal, Envarsus XR, Talymus EU 特应性皮炎 Leo Pharma A/S 1993-01-01 狼疮肾炎, 特应性皮炎, 冠状动脉再狭窄, 角结膜炎, 心脏移植排斥, 溃疡性结肠炎, 哮喘, 变应性结膜炎, 银屑病, 器官移植排斥, 结膜炎, 重症肌无力, 类风湿关节炎, 移植物抗宿主病, 肝脏移植排斥, 膀胱炎, 角膜移植排斥反应, 免疫球蛋白a肾病, 肾功能不全, 肝功能衰竭, 肾脏移植排斥 详情

FKBP12临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Rimiducid AP-1903 临床二期 Ariad Pharmaceuticals Inc 前列腺癌, 先天性骨髓衰竭综合征, 镰状细胞血症, 噬血细胞性淋巴组织细胞增多症, 胰腺导管癌, 非霍奇金淋巴瘤, 淋巴瘤, 急性髓细胞样白血病, 泌尿生殖道肿瘤, 代谢病, 骨硬化症, 再生障碍性贫血, 急性淋巴细胞白血病, 原发性免疫缺陷疾病, 葡萄膜黑色素瘤, 多发性骨髓瘤, 去势抵抗性前列腺肿瘤, 胰腺癌, 范科尼贫血, 先天性单纯性红细胞再生障碍性贫血, 血红蛋白病, 骨髓增生异常综合征, 地中海贫血, 男性生殖器官肿瘤, 血液肿瘤, 白血病 详情

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