Recombinant Proteins iso9001 ISO13485
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 > 【FGF R4】重组蛋白信息

FGF R4信息

英文名称:Fibroblast growth factor receptor 4
中文名称:成纤维细胞生长因子受体-4
靶点别称:EC:2.7.10.1,Fibroblast growth factor receptor 4,CD334,FGFR4,TKF,JTK2,Tyrosine Kinase Related To Fibroblast Growth Factor Receptor,Hydroxyaryl-Protein Kinase,Protein-Tyrosine Kinase,Tyrosylprotein Kinase,CD334 Antigen,EC 2.7.10.1,FGFR-4,EC 2.7.10,Receptor,
上市药物数量:2
临床药物数量:10
最高研发阶段:批准上市

FGF R4产品列表

产品库
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
FG4-H5228
Human
Human FGF R4 / CD334 Protein, His Tag
FG4-M52Ha
Mouse
Mouse FGF R4 / CD334 Protein, His Tag
 
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FGF R4 分子别名

FGFR4,CD334,JTK2,MGC20292,TKF

FGF R4 分子背景

Fibroblast growth factor receptor 4(FGFR4) is also known as CD334, JTK2, hydroxyaryl-protein kinase, TKF, protein-tyrosine kinase . The FGFR4 gene provides instructions for making a protein called fibroblast growth factor receptor 4. This protein is part of a family of fibroblast growth factor receptors that share similar structures and functions. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development.The FGFR4 protein interacts with specific growth factors to conduct signals from the environment outside the cell to the nucleus. The nucleus responds to these signals by switching on or off appropriate genes that help the cell adjust to changes in the environment. In response, the cell might divide, move, or mature to take on specialized functions. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. The FGFR4 gene may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.

FGF R4 参考文献

FGF R4上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Erdafitinib G-024; JNJ-493; 890E37NHMV; JNJ-42756493 批准上市 Astex Pharmaceuticals Inc Balversa United States 移行细胞癌 Janssen Biotech Inc 2019-04-12 实体瘤, 癌, 胃癌, 食道癌, 移行细胞癌, 膀胱癌, 泌尿系肿瘤, 胆道癌, 肝功能衰退, 淋巴瘤, 肝细胞癌, 非小细胞肺癌, 腺癌 详情
Lenvatinib Mesylate 甲磺酸仑伐替尼 ER-203492-00; E-7080 批准上市 卫材株式会社 Kisplyx, Lenvima, Lenvima/Kisplyx, 乐卫玛 Mainland China 肝细胞癌 Eisai Europe Ltd 2015-02-13 实体瘤, 肝癌, 胆管癌, 卵巢癌, 肾细胞癌, 肺腺癌, 甲状腺未分化癌, 肾脏疾病, 骨肉瘤, 肝功能衰退, 甲状腺瘤, 淋巴瘤, 子宫内膜样癌, 肝细胞癌, 非小细胞肺癌, 黑色素瘤 详情

FGF R4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
PRN-1371 PRN-1371 临床一期 Principia Biopharma 肿瘤, 膀胱癌 详情
ABSK-011 ABSK-011 临床一期 上海和誉生物医药科技有限公司 肝癌
H3B-6527 H3B-6527 临床一期 H3 Biomedicine 肝癌, 胆管上皮癌, 肝细胞癌 详情
LY-2874455 LY-2874455 临床二期 礼来制药 肿瘤 详情
ICP-105 ICP-105 临床一期 北京天诚医药科技有限公司, 南京天印健华医药科技有限公司, 北京诺诚健华医药科技有限公司 肝癌 详情
BPI-43487 BPI-43487 临床一期 贝达药业股份有限公司 胆管癌, 肝细胞癌
Roblitinib FGF-401; NVP-FGF401 临床二期 诺华制药 实体瘤, 肿瘤, 肝细胞癌 详情
Fisogatinib BLU-554; CS-3008 临床二期 Blueprint Medicines Corporation 肝细胞癌 详情
Aldafermin M-70; NGM-282 临床二期 Ngm Biopharmaceuticals 胆汁性肝硬化, 便秘, 非酒精性脂肪肝, 二型糖尿病, 肾功能不全, 纤维化, 原发性硬化性胆管炎, 糖尿病 详情
Futibatinib TAS-120 临床三期 Otsuka Pharmaceutical Co Ltd, 大鹏药品工业株式会社 实体瘤, 食道癌, 胃癌, 癌, 移行细胞癌, 脑癌, 胆管上皮癌, 乳腺癌 详情

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