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> 【FABP6】
FABP6信息
英文名称：Bile acid binding protein
中文名称：胆汁酸结合蛋白
靶点别称：ILBP3，Gastrotropin，Intestinal Bile Acid-Binding Protein，Fatty Acid Binding Protein 6， Ileal，Intestinal 15 KDa Protein，I-BABP，Fatty Acid-Binding Protein 6，I-BALB，I-BAP，ILLBP，Ileal Bile Acid Binding Protein，ILBP，Fatty Acid Binding Protein 6，Illeal Lipid-Binding Protein，Ileal Lipid-Binding Protein，I-15P，FABP6，GT
中文名称：胆汁酸结合蛋白
靶点别称：ILBP3，Gastrotropin，Intestinal Bile Acid-Binding Protein，Fatty Acid Binding Protein 6， Ileal，Intestinal 15 KDa Protein，I-BABP，Fatty Acid-Binding Protein 6，I-BALB，I-BAP，ILLBP，Ileal Bile Acid Binding Protein，ILBP，Fatty Acid Binding Protein 6，Illeal Lipid-Binding Protein，Ileal Lipid-Binding Protein，I-15P，FABP6，GT
上市药物数量：2
临床药物数量：2
最高研发阶段：批准上市
临床药物数量：2
最高研发阶段：批准上市
FABP6 分子别名
FABP6,ILBP,ILLBP,Gastrotropin,GT,I-15P,I-BABP,I-BALB,I-BAP
FABP6 分子背景
Fatty acid-binding protein 6 (FABP6), is also known as Intestinal bile acid-binding protein (I-BABP), Ileal lipid-binding protein (ILBP), Intestinal 15 kDa protein (I-15P), Gastrotropin (GT). FABP6 is a cytoplasm protein which belongs to the calycin superfamily and fatty-acid binding protein (FABP) family. Isoform 2 of FABP6 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 of FABP6 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Ileal protein FABP6 stimulates gastric acid and pepsinogen secretion. FABP6 seems to be able to bind to bile salts and bilirubins. Isoform 2 of FABP6 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.
FABP6 前沿进展
FABP6上市药物信息
| 英文名称 | 中文名称 | 研发代码 | 研发阶段 | 公司 | 最早商品名 | 最早批准国家 | 最早适应症 | 最早批准公司 | 最早批准日期 | 适应症 | 临床试验 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Colestipol Hydrochloride | 盐酸考来替泊 | 批准上市 | 辉瑞制药有限公司 | Colestid | United States | 高脂血症 | Pharmacia & Upjohn | 1977-04-04 | 高脂血症 | 详情 | |
| Colesevelam Hydrochloride | 盐酸考来维仑 | GT31-104HB; GT-31104; GT31-104 | 批准上市 | 美国健赞公司 | CholestaGel, Welchol, Colestagel | EU | 高胆固醇血症 | Genzyme Europe Bv | 2000-05-26 | 非酒精性脂肪肝, 二型糖尿病, 高胆固醇血症, 多发性骨髓瘤, 杂合子家族性高胆固醇血症, II型高脂蛋白血症, 高脂血症 | 详情 |
