Recombinant Proteins iso9001 ISO13485
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 > 【EMMPRIN】重组蛋白信息

EMMPRIN信息

英文名称:Basigin
中文名称:Basigin蛋白
靶点别称:Extracellular matrix metalloproteinase inducer,UNQ6505/PRO21383,Basigin (Ok Blood Group),Tumor Cell-Derived Collagenase Stimulatory Factor,Leukocyte Activation Antigen M6,Collagenase Stimulatory Factor,Basigin,5F7,Ok Blood Group,CD147 Antigen,EMPRIN,CD147
上市药物数量:1
临床药物数量:3
最高研发阶段:批准上市

EMMPRIN Molecule Synonym Name

Basigin,BSG,5F7,CD147,EMMPRIN,M6,OK,TCSF

EMMPRIN 分子背景

CD147, also known as Basigin (BSG), or extracellular matrix metalloproteinase inducer (EMMPRIN). The human basigin protein contains 269 amino acids that form two heavily glycosylated C2 type immunoglobulin-like domains at the N-terminal extracellular portion. A second form of basigin has also been characterized that contains one additional immunoglobulin-like domain in its extracellular portion. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition and regulate several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. Basigin is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins.

EMMPRIN 参考文献

EMMPRIN上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Iodine[131I] Metuximab 碘[131I]美妥昔单抗 批准上市 成都华神生物技术有限责任公司 利卡汀, Licartin Mainland China 肝细胞癌 Chengdu Huasun Biotechnology Co Ltd 2006-10-12 肝细胞癌 详情

EMMPRIN临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Meplazumab HI6H8 临床三期 江苏太平洋美诺克生物药业有限公司, 第四军医大学 疟原虫感染, 新型冠状病毒肺炎 详情
Anti-CD147 CAR T cell therapy (Xijing Hospital) 临床一期 西京医院 胶质母细胞瘤 详情
Mertuzumab 临床一期 江苏太平洋美诺克生物药业有限公司, 第四军医大学 非小细胞肺癌 详情

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