英文名称：Sodium channel protein type VIII alpha subunit 中文名称：VIII型钠通道蛋白α亚基 靶点别称：MYOCL2，Sodium Channel， Voltage Gated， Type VIII， Alpha Subunit，Sodium Channel， Voltage Gated， Type VIII Alpha Subunit，NAV1.6 Voltage-Gated Sodium Channel，Sodium channel protein type 8 subunit alpha，Sodium channel protein type VIII subunit alpha，MED，SCN8A，Sodium Voltage-Gated Channel Alpha Subunit 8，Voltage-Gated Sodium Channel Subunit Alpha Nav1.6，Sodium Channel， Voltage Gated， Type VIII， Alpha Polypeptide，Voltage-Gated Sodium Channel Type VIII Alpha Protein，HNa6/Scn8a Voltage-Gated Sodium Chann
Cartilage oligomeric matrix protein (COMP) is also known as Thrombospondin-5 (TSP5), EDM1, EPD1, MED, PSACH, THBS5, which belongs to the thrombospondin family. COMP / TSP5 contains 4 EGF-like domains, 1 TSP C-terminal (TSPC) domain, 8 TSP type-3 repeats. Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. COMP can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Thrombospondin-5 could play a role in the pathogenesis of osteoarthritis. COMP is a marker of cartilage turnover.