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CD98信息

英文名称:L-type amino acid transporter 1
中文名称:L-型氨基酸转运蛋白-1
靶点别称:D16S469E,Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 5,LAT1,SLC7A5,Y+ System Cationic Amino Acid Transporter,4F2LC,4F2 LC,Large Neutral Amino Acid-Transporter 1,Large Neutral Amino Acids Transporter Small Subunit 1,Solute Carrier Family 7 Member 5,HLAT1,CD98LC,CD98,Sodium-Independent Neutral Amino Acid Transporter LAT1,L-Type Amino Acid Transporter 1,4F2 Light Chain,E16,Solute Carrier Family 7 (Amino Acid Transporter Light Chain, L System), Member 5,MPE16,Integra
上市药物数量:0
临床药物数量:6
最高研发阶段:临床二期

CD98产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CD8-H5247
Human
Human CD98 Protein, His Tag (MALS verified)
CD8-HF248
Human
FITC-Labeled Human CD98 Protein, His Tag
 
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CD98 分子别名

SLC3A2,CD98,4F2,4F2HC,4T2HC,CD98HC,MDU1,NACAE

CD98 分子背景

CD antigen CD98 is also known as 4F2 cell-surface antigen heavy chain (4F2hc), 4F2 heavy chain antigen, Solute carrier family 3 member 2 (SLC3A2), Lymphocyte activation antigen 4F2 large subunit, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family.. SLC3A2 / CD98 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. SLC3A2 / CD98 is required for the function of light chain amino-acid transporters and also involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. CD98 involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A5 or SLC7A8, CD98 involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals.

CD98 前沿进展

CD98临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
JPH-203 JPH-203; KYT-0353; JPH-203SBECD 临床二期 J-Pharma 胆管癌 详情
R-OKY-034F R-OKY-034F 临床二期 大阪大学, Japan Agency For Medical Research And Development 胰腺癌 详情
[18F]AA-7 [18F]AA-7 临床阶段不明 大阪市立大学, Institute Physical Chemical Research (Riken), Nagase Medicals 胶质瘤 详情
QBS-10072S QBS-10072S 临床一期 Novotech (Australia) Pty Ltd 肉瘤, 宫颈癌, 舌肿瘤, 黑色素瘤, 转移癌, 肺癌, 脑转移, 胸腺瘤, 中枢神经系统紊乱, 泌尿系肿瘤, 结直肠癌, 星形细胞瘤, 前列腺癌, 肝癌, 脑癌, 乳腺癌, 胆管上皮癌, 膀胱癌, 间皮组织肿瘤, 胰腺癌, 胃癌, 食道癌, 肾肿瘤, 头颈癌, 卵巢癌 详情
NBQ72S NBQ72S 临床一期 脑癌 详情
TLX-101 131I-IPA; 131I-ACD-101 临床二期 Telix Pharmaceuticals 乳腺癌 详情
TLX101-CDx TLX-101-CDx; 18F-FET 临床二期 Telix Pharmaceuticals Ltd 乳腺癌 详情

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