膜杰作
Star Staining
ViruStop
Aneuro
ComboX
ActiveMax
GENPower
ClinMax
> 【CD74】
CD74信息
英文名称：HLA-DR antigens-associated invariant chain
中文名称：HLA-DR抗原相关不变链
靶点别称：CLIP，CD74，Ia antigen-associated invariant chain，CD74 Molecule，CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex， Class II Antigen-Associated)，CD74 Molecule， Major Histocompatibility Complex， Class II Invariant Chain，HLA-DR Antigens-Associated Invariant Chain，Ia-Associated Invariant Chain，MHC HLA-DR Gamma Chain，HLA-DR-Gamma，DHLAG，P33，CD74 Antigen，Ia-GAMMA，HLADG，II，Gamma Chain Of Class II Antigens，HLA Class II Histocompatibility Antigen Gamma Chain
中文名称：HLA-DR抗原相关不变链
靶点别称：CLIP，CD74，Ia antigen-associated invariant chain，CD74 Molecule，CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex， Class II Antigen-Associated)，CD74 Molecule， Major Histocompatibility Complex， Class II Invariant Chain，HLA-DR Antigens-Associated Invariant Chain，Ia-Associated Invariant Chain，MHC HLA-DR Gamma Chain，HLA-DR-Gamma，DHLAG，P33，CD74 Antigen，Ia-GAMMA，HLADG，II，Gamma Chain Of Class II Antigens，HLA Class II Histocompatibility Antigen Gamma Chain
上市药物数量：0
临床药物数量：3
最高研发阶段：临床二期
临床药物数量：3
最高研发阶段：临床二期
CD74产品列表
| 货号 | 物种 | 产品描述 | 蛋白结构 | 纯度 | 活性 |
|---|---|---|---|---|---|
| CD4-H524c |
 Human |
Human CD74 / DHLAG Protein, His Tag |
 |
  |
|
| CD4-H5256 |
Human |
Human CD74 / DHLAG Protein, Fc Tag (MALS verified) |
 |
 |
评论(1)
CD4-H524c|Human CD74 / DHLAG Protein, His Tag
- 139XXXXXXX9
- CD47带有his标签的靶点蛋白，经过和商业化抗体qc后，亲和力达到标准，用于小鼠免疫和杂交瘤的后期筛选，以拿到好亲和力的抗体进行后续人源化。
- 2021-12-08
3人赞
CD74 分子别名
CD74,DHLAG,HLADG,II,Ia-GAMMA,p33,CLIP,INVG34
CD74 分子背景
Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.
CD74 前沿进展
CD74临床药物信息
| 英文名称 | 研发代码 | 研发阶段 | 公司 | 适应症 | 临床试验 |
|---|---|---|---|---|---|
| Milatuzumab | hLL1; hCD74; IMMU-115 | 临床二期 | Immunomedics | 慢性髓细胞白血病, 盘状红斑狼疮, 淋巴细胞性白血病, 浆细胞瘤, 移植物抗宿主病, 皮肤红斑狼疮, 骨髓增生异常综合征, 多发性骨髓瘤, 狼疮肾炎, 系统性红斑狼疮, 急性淋巴细胞白血病, 狼疮血管炎，中枢神经系统, 非霍奇金淋巴瘤, 慢性淋巴细胞白血病 | 详情 |
| Influenza A M1 vaccine (Pascal Biosciences) | 临床一期 | Pascal Biosciences | 甲型流感病毒感染 | 详情 | |
| Anti-CD 74 antibody drug conjugates(Sutro Biopharma) | STRO-001; BN-301 | 临床一期 | 烨辉医药科技（上海）有限公司, Sutro Biopharma Inc | B-细胞淋巴瘤, 弥漫性大B-细胞淋巴瘤, 多发性骨髓瘤, 滤泡中心淋巴瘤, 套细胞淋巴瘤, 非霍奇金淋巴瘤 | 详情 |
