CD74 靶点蛋白|抗体药物|临床药物信息

CD74信息

英文名称：HLA-DR antigens-associated invariant chain
中文名称：HLA-DR抗原相关不变链
靶点别称：CLIP，CD74，Ia antigen-associated invariant chain，CD74 Molecule，CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex， Class II Antigen-Associated)，CD74 Molecule， Major Histocompatibility Complex， Class II Invariant Chain，HLA-DR Antigens-Associated Invariant Chain，Ia-Associated Invariant Chain，MHC HLA-DR Gamma Chain，HLA-DR-Gamma，DHLAG，P33，CD74 Antigen，Ia-GAMMA，HLADG，II，Gamma Chain Of Class II Antigens，HLA Class II Histocompatibility Antigen Gamma Chain

上市药物数量：0
临床药物数量：3
最高研发阶段：临床一期

CD74产品列表

筛选结果

产品库

在线 (3)

物种

Human (3)

标签

属性

Protein (3)

标记

Unconjugated (3)

货号	物种	产品描述
CD4-H524c	Human	Human CD74 / DHLAG Protein, His Tag
CD4-H5256	Human	Human CD74 / DHLAG Protein, Fc Tag (MALS verified)
CD4-H5258	Human	Human CD74 / DHLAG Protein, Llama IgG2b Fc Tag, low endotoxin

CD4-H524c|Human CD74 / DHLAG Protein, His Tag

139XXXXXXX9

3人赞

CD47带有his标签的靶点蛋白，经过和商业化抗体qc后，亲和力达到标准，用于小鼠免疫和杂交瘤的后期筛选，以拿到好亲和力的抗体进行后续人源化。
2021-12-08

CD74 分子别名

CD74,DHLAG,HLADG,II,Ia-GAMMA,p33,CLIP,INVG34

CD74 分子背景

Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.

CD74 前沿进展

CD74临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Influenza A M1 vaccine (Pascal Biosciences)		临床一期	Pascal Biosciences	甲型流感病毒感染	详情
IMMU-114	hL243; IMMU-114		Immunomedics Inc		详情
Milatuzumab doxorubicin	IMMU-110; hLL1-DOX; CD-74-DOX; hCD74-DOX		Immunomedics Inc		详情
Milatuzumab	hLL1; hCD74; IMMU-115		Immunomedics		详情
BN-301	STRO-001; BN-301	临床一期	烨辉医药科技（上海）有限公司, Sutro Biopharma Inc	B-细胞淋巴瘤, 弥漫性大B-细胞淋巴瘤, 多发性骨髓瘤, 套细胞淋巴瘤, 滤泡中心淋巴瘤, 非霍奇金淋巴瘤	详情

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CD74