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CD5信息

英文名称:T-cell surface glycoprotein CD5
中文名称:T细胞表面糖蛋白CD5
靶点别称:CD5,Lymphocyte antigen T1/Leu-1,T-cell surface glycoprotein CD5,CD5 Molecule,CD5 Antigen (P56-62),LEU1,CD5 Antigen,T1,CD5 Antigens,Epididymis Secretory Sperm Binding Protein
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

CD5 分子别名

CD5,LEU1

CD5 分子背景

T-cell surface glycoprotein CD5 is also known as Lymphocyte antigen T1/Leu-1 and LEU1,which is phosphorylated on tyrosine residues by LYN,so CD5 can create binding sites for PTPN6/SHP-1.CD5 may act as a receptor in regulating T-cell proliferation. CD5 is expressed at various developmental and activation stages on human B cells.CD5 is a well established negative regulator of TCR and BCR signalling.CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. Development,selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.

CD5 前沿进展

CD5临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
CD5 CAR T Cell Therapy (Beijing Boren Hospital) 临床一期 北京博仁医院 前体T-淋巴母细胞性淋巴瘤白血病 详情
CT-125A CT-125A; RD-125 临床一期 南京驯鹿医疗技术有限公司 周围T-细胞淋巴瘤, 套细胞淋巴瘤, 浆母细胞淋巴瘤, 滤泡中心淋巴瘤, 慢性淋巴细胞白血病 详情

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