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CD46信息

英文名称:Membrane cofactor protein
中文名称:膜辅因子蛋白
靶点别称:TLX,MCP,CD46,CD46 Molecule,Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen),Antigen Identified By Monoclonal Antibody TRA-2-10,CD46 Molecule, Complement Regulatory Protein,CD46 Antigen, Complement Regulatory Protein,Trophobl
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

CD46产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
CD6-H5226
Human
Human CD46 Protein, His Tag
 
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CD46 分子别名

CD46,AHUS2,MCP,MIC10,TLX,TRA2.10

CD46 分子背景

Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

CD46 前沿进展

CD46临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
FOR-46 FOR-46 临床一期 圣迭戈加利福尼亚大学 多发性骨髓瘤, 前列腺癌 详情
Enadenotucirev ColoAd-1; Oncolytic Ad11/Ad3 临床二期 Psioxus Therapeutics 卵巢癌, 头颈癌, 头颈部鳞状细胞癌, 肾细胞癌, 腺性和上皮性肿瘤, 结肠癌, 膀胱癌, 结直肠癌, 泌尿生殖道肿瘤, 非小细胞肺癌 详情

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