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CD44信息

英文名称:CD44 antigen
中文名称:CD44抗原
靶点别称:Hermes Antigen,Hyaluronate Receptor,Cell Surface Glycoprotein CD44,MC56,PGP-1,CD44,CDW44,GP90 Lymphocyte Homing/Adhesion Receptor,MIC4,LHR,Hematopoietic Cell E- And L-Selectin Ligand,CD44 Antigen (Homing Function And Indian Blood Group System),MDU3,Extracellular Matrix Receptor III,Heparan Sulfate Proteoglycan,HUTCH-I,ECMR-III,Epican,Chondroitin Sulfate Proteoglycan 8,Soluble CD44,MDU2,Pgp1,CSPG8,HCELL,Phagocytic Glycoprotein 1,Indian Blood Group Antigen,IN,Phagocytic Glycoprotein I,CD44 Molecul
上市药物数量:0
临床药物数量:10
最高研发阶段:临床三期

CD44产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
CD4-H5226
Human
Human CD44 Protein, His Tag
PG1-H5255
Human
Human CD44 Protein, Fc Tag (HPLC-verified)
 
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CD44 分子别名

CD44,CDW44,CSPG8,ECMR-III,HCELL,HUTCH-I,IN,LHR,MC56,MDU2,MDU3,MIC4,Pgp1,Epican

CD44 分子背景

CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. CD44 is expressed in a large number of mammalian cell types. CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms.

CD44 前沿进展

CD44临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Clodronic acid/Hyaluronic acid 临床一期 意大利Abiogen制药股份公司 骨关节炎 详情
Hyaluronic acid/Fluorouracil HA-5FU; HA-5-fluorouracil; Hyaluronic acid-5-fluorouracil complex; Hyaluronan acid-5-fluorouracil complex 临床二期 莫纳什大学, Alchemia 结直肠癌 详情
BGC-0228 BGC-0228 临床一期 博瑞生物医药(苏州)股份有限公司 实体瘤 详情
ALM-201 ALM-201; FKBPL; FKBP-L Almac Discovery 眼部疾病 详情
MLM-CAR44.1 T-cell therapy (MolMed) Molmed 详情
Multiple 4SCAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) 深圳市免疫基因治疗研究院 详情
Bivatuzumab BIWA-4; anti-CD44; anti-CD44 monoclonals 勃林格殷格翰 详情
RG-7356 RG-7356; RO-5429083 罗氏, 中外制药株式会社 详情
Bivatuzumab mertansine BIWI-1 Immunogen, 勃林格殷格翰 详情
AMC-303 AMC-303; HP-558 临床一期 Amcure 食管鳞状细胞癌 详情
CA-102N CA-102N Biobud 详情
CD44v6-specific CAR gene-engineered T cell therapy (Shenzhen Geno-Immune Medical Institute) 4SCAR-CD44v6 临床二期 深圳市免疫基因治疗研究院 肿瘤 详情
Paclitaxel/Hyaluronic acid 临床三期 Fidia Pharma 乳头状癌, 膀胱癌 详情
Hydrogen peroxide/Hyaluronic acid BMG-0703 临床三期 University Of Milan 磨牙症, 牙龈出血, 牙龈炎, 手术创口, 牙周炎 详情
Hyaluronic acid ETX-100; CTX-100 临床三期 Actelion Pharmaceuticals Ltd 指甲嵌入肉, 新型冠状病毒肺炎, 牙龈萎缩, 膝关节炎, 噪声性听力损失, 突发性听力损失, 美尼尔氏症 详情

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