Recombinant Proteins iso9001 ISO13485
搜索
 > 【CD40 Ligand】重组蛋白信息

CD40 Ligand信息

英文名称:CD40 ligand
中文名称:CD40配体
靶点别称:CD154 Antigen,HCD40L,CD154,T-BAM,HIGM1,Gp39,IMD3,IGM,CD40 Ligand,TNFSF5,CD40L,CD40 ligand, soluble form,CD40 ligand, membrane form,Tumor necrosis factor ligand superfamily member 5,T-cell antigen Gp39,CD40-L,CD40LG,TNF-Related Activation Protein,Tumor Nec
上市药物数量:0
临床药物数量:11
最高研发阶段:临床三期

CD40 Ligand产品列表

 
评论(2)
CDL-H5248|Human CD40 Ligand / TNFSF5 Protein, His Tag
  1. 131XXXXXXX1
  2. 4人赞
  3. CD40L-His蛋白买过来是用来做细胞功能检测的,这个产品在体外激活细胞信号通路的效果非常好,细胞增殖曲线很完美~
  4. 2019-11-11
CDL-H5248|Human CD40 Ligand / TNFSF5 Protein, His Tag
  1. 182XXXXXXX2
  2. 2人赞
  3. Human CD40L买的His标签的,用来与CD40测亲和力的,拉浓度梯度做下来,亲和力在5*10-9
  4. >
  5. 2019-10-10
 

CD40 Ligand Molecule Synonym Name

CD40LG,CD154,CD40L,HIGM1,IGM,IMD3,T-BAM,TNFSF5,TRAP,gp39

CD40 Ligand 分子背景

CD40 ligand is also known as CD40L, CD154, TNFSF5 and T-cell antigen Gp39, is a single-pass type I I membrane protein which belongs to the TNF superfamily of molecules. CD40 ligand is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells). Although all monomeric, dimeric and trimeric forms of soluble CD40 ligand can bind to CD40, the trimeric form of soluble CD40 ligand has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members. CD40 ligand binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40 ligand plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40 ligand has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome.

CD40 Ligand 参考文献

CD40 Ligand临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AdCD40L 临床二期 Uppsala University 膀胱癌, 黑色素瘤
BIIB-063 BIIB-063 临床一期 百健 Sjtoegren综合征 详情
INX-021 INX-021; SAR-441344 临床二期 Immunext 多发性硬化, Sjogren-Larsson综合征 详情
ABBV-428 ABBV428; ABBV-428 临床一期 艾伯维 肿瘤 详情
Letolizumab BMS-986004; BMS2h-572-633-CT-L2 临床二期 百时美施贵宝 特发性血小板减少性紫癜 详情
rVV-740CTA vaccine (University Hospital Basel) rVV-740CTA 临床一期 University Hospital Basel 乳腺癌 详情
Anti-CD40L antibody (Bristol-Myers Squibb) 临床二期 百时美施贵宝 免疫缺陷性疾病
Dazodalibep VIB-4920; MEDI-4920 临床二期 Medimmune Llc 肾脏移植排斥, Sjtoegren综合征, 类风湿关节炎, Sjogren-Larsson综合征 详情
Delolimogene mupadenorepvec LOAd-703 临床二期 Lokon Pharma, Uppsala University 胆管癌, 卵巢癌, 胰腺癌, 结直肠癌, 黑色素瘤 详情
Dapirolizumab pegol Anti-CD40L-Fab; Anti-CD40L-Fab-PEG; CDP-7657; CD40L - Fab; BIIB-133 临床三期 百健, 比利时优时比制药有限公司 自身免疫疾病, 结缔组织疾病, 系统性红斑狼疮 详情
AT-1501 AT-1501 临床二期 Als Therapy Development Institute, Anelixis Therapeutics Inc 1型糖尿病, 肌萎缩性侧索硬化 详情

消息提示

请输入您的联系方式,再点击提交!

确定