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CD40 Ligand信息

英文名称:CD40 ligand
中文名称:CD40配体
靶点别称:CD154 Antigen,HCD40L,CD154,TNFSF5,CD40L,CD40 ligand, soluble form,CD40 ligand, membrane form,Tumor necrosis factor ligand superfamily member 5,T-cell antigen Gp39,CD40-L,CD40LG,TNF-Related Activation Protein,Tumor Necrosis Factor (Ligand) Superfamily Member 5,T-B Cell-Activating Molecule,T-BAM,HIGM1,Gp39,IMD3,IGM,CD40 Ligand,CD40 Antigen Ligand,TRAP,Tumor Necrosis Factor (Ligand) Superfamily, Member 5 (Hyper-IgM Syndrome),Hyper-IgM Syndrome,sCD40L
上市药物数量:0
临床药物数量:12
最高研发阶段:临床三期

CD40 Ligand产品列表

 
评论(4)
CDL-H52Db|Human CD40 Ligand / TNFSF5 Protein, His,Flag Tag (active trimer) (MALS verified)
  1. 139XXXXXXX3
  2. 2人赞
  3. 用于抗体筛选工作,目前方法建立顺利进行中,抗原能很好的溶解和包被,提供的技术支持也比较完善,试验中出现的问题都能给予多方面的支持
  4. >
  5. 2021-11-11
CDL-H82F1|Biotinylated Human CD40 Ligand / TNFSF5 Protein, Avitag™,Fc Tag
  1. 150XXXXXXX0
  2. 2人赞
  3. 关注CD40靶点开发,购买了CD40ligand用于活性检测。 蛋白纯度符合要求,批次间稳定 同时用这个产品作为自己表达抗原蛋白的阳性对照样品,助力新药发现
  4. 2021-11-03
CDL-M5248|Mouse CD40 Ligand / TNFSF5 Protein, His Tag (active trimer) (MALS verified)
  1. 176XXXXXXX6
  2. 0人赞
  3. 关注CD40靶点开发,购买了CD40ligand用于活性检测。 蛋白纯度符合要求,批次间稳定 同时用这个产品作为自己表达抗原蛋白的阳性对照样品,助力新药发现
  4. >
  5. 2022-02-08
 

CD40 Ligand 分子别名

CD40LG,CD154,CD40L,HIGM1,IGM,IMD3,T-BAM,TNFSF5,TRAP,gp39,CD40 Ligand,CD40-LG,CD40 L

CD40 Ligand 分子背景

CD40 ligand is also known as CD40L, CD154, TNFSF5 and T-cell antigen Gp39, is a single-pass type I I membrane protein which belongs to the TNF superfamily of molecules. CD40 ligand is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells). Although all monomeric, dimeric and trimeric forms of soluble CD40 ligand can bind to CD40, the trimeric form of soluble CD40 ligand has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members.CD40 ligand binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40 ligand plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40 ligand has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome.

CD40 Ligand 前沿进展

CD40 Ligand临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AdCD40L 临床二期 Uppsala University 膀胱癌, 黑色素瘤 详情
Anti-CD40L antibody (Bristol-Myers Squibb) 临床二期 免疫缺陷性疾病 详情
APB-A1 APB-A1; Lu-AG22515 临床一期 AprilBio Co Ltd 视神经脊髓炎 详情
MEM-288 MEM-288 Memgen 详情
Frexalimab INX-021; SAR-441344 Immunext 详情
rVV-740CTA vaccine (University Hospital Basel) rVV-740CTA University Hospital Basel 详情
Delolimogene mupadenorepvec LOAd-703 Uppsala University, Lokon Pharma 详情
Letolizumab BMS-986004; BMS2h-572-633-CT-L2 百时美施贵宝 详情
Dapirolizumab pegol Anti-CD40L-Fab; Anti-CD40L-Fab-PEG; CDP-7657; CD40L - Fab; BIIB-133 临床三期 百健, 比利时优时比制药有限公司 系统性红斑狼疮 详情
iHIVARNA-01 iHIVARNA-01 Idibaps 详情
Tegoprubart AT-1501 临床二期 Als Therapy Development Institute, Anelixis Therapeutics Llc 肾脏移植排斥, 一型糖尿病, 免疫球蛋白a肾病, 肌萎缩性侧索硬化 详情

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