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CD4信息

英文名称:T-cell surface antigen CD4
中文名称:T细胞表面抗原CD4
靶点别称:CD4mut,CD4 Antigens,T-cell surface antigen T4/Leu-3,T-cell surface glycoprotein CD4,CD4,CD4 Molecule,CD4 Antigen (P55),CD4 Receptor,CD4 Antigen
上市药物数量:1
临床药物数量:24
最高研发阶段:批准上市

CD4产品列表

ACRO质量管理体系
 
评论(2)
LE3-H5228|Human CD4 / LEU3 Protein, His Tag (MALS verified) DMF Filed
  1. 182XXXXXXX6
  2. 3人赞
  3. human CD His该蛋白我们用于免疫羊驼及Elisa验证实验,免疫效果好,亲和力高,实验数据稳定,重复性好,性价比高,值得信赖。
  4. >
  5. 2022-02-21
CD4-C52H7|Rhesus macaque CD4 Protein, His Tag (MALS verified)
  1. 176XXXXXXX7
  2. 1人赞
  3. 新购入一个糖基化磷脂酰肌醇锚定蛋白Mouse CD24 Protein, His Tag,ACRO果然物美价廉~赞
  4. 2022-09-08
 

CD4 分子别名

CD4,CD4mut,LEU3

CD4 分子背景

Cluster of Differentiation 4 (CD4) is also known as T-cell surface antigen T4/Leu-3 (LEU-3) and CD4mut, is a single-pass type I  membrane glycoprotein,and is a member of the immunoglobulin superfamily. CD4 expressed on the surface of T helper cells, monocytes, macrophages, and dendritic cells. It has four immunoglobulin domains (D1 to D4) that are exposed on the extracellular surface of the cell: D1 and D3 resemble immunoglobulin variable (IgV) domains. D2 and D4 resemble immunoglobulin constant (IgC) domains. CD4 is a co-receptor that assists the T cell receptor (TCR) with an antigen-presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR by recruiting an enzyme, known as the tyrosine kinase lck, which is essential for activating many molecules involved in the signaling cascade of an activated T cell. CD4 also interacts directly with MHC class II molecules on the surface of the antigen-presenting cell using its extracellular domain. The extracellular domain adopts an immunoglobulin-like beta-sandwich with seven strands in 2 beta sheets, in a Greek key topology. CD4 has also been shown to interact with SPG21, Lck and Protein unc-119 homolog. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.

CD4 前沿进展

CD4上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Ibalizumab Hu5A8; TMB-355; TNX-355; 5AB 批准上市 百健 特罗格佐, Trogarzo EU HIV感染 Theratechnologies Europe Ltd 2018-03-06 HIV感染 详情

CD4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
IT-1208 (Kyowa Hakko Kirin) IT-1208 临床一期 Kyowa Hakko Kirin Co Ltd 肿瘤 详情
TMB-365 TMB-365 临床一期 中裕新药股份有限公司 HIV感染 详情
GEN-009 GEN-009 临床二期 Genocea Biosciences Inc 皮肤黑色素瘤, 肾细胞癌, 头颈部鳞状细胞癌, 尿路上皮癌, 非小细胞肺癌 详情
VRC-07-523 VRC-07-523-L S; VRC-HIVMAB075-00-AB; VRC-HIVMAB-075 -00-AB; VRC-07-523; TMB-380 临床二期 National Institute Of Allergy And Infectious Diseases (Niaid), 中裕新药股份有限公司 HIV感染, 获得性免疫缺损综合征, 逆转录病毒感染, 病毒性性传播疾病 详情
Mosedipimod EC-18 临床二期 Enzychem Lifesciences Co 中性粒细胞减少, 新型冠状病毒肺炎, 口腔炎, 发热性中性粒细胞减少症 详情
VRC-01-LS VRC-HIVMAB-080-00-AB; VRC-01-LS 临床二期 National Institute Of Allergy And Infectious Diseases (Niaid) HIV感染 详情
IMCY-0141 IMCY-0141 临床二期 Imcyse Sa 复发-缓解型多发性硬化 详情
RB-0003 RB-0003; BNT-111 临床二期 Biontech Se, Tron 黑色素瘤 详情
T-allo-10 T-allo-10 临床一期 斯坦福大学 血液疾病, 移植物抗宿主病 详情
VRC-HIVMAB0115-00-AB 临床一期 National Institute Of Allergy And Infectious Diseases (Niaid) HIV感染 详情
CALRLong36 peptide (Herlev Hospital) 临床一期 Herlev Hospital 骨髓增生性疾病 详情
Anti-CD4 CAR T-cell therapy (University of Pennsylvania) CAR-C34ZFN 临床一期 宾夕法尼亚大学 HIV感染 详情
10E8.4/iMab (Aaron Diamond AIDS Research Center) TMB-370 临床一期 Aaron Diamond Aids Research Center For The City Of New York, Inc HIV感染 详情
CD4-directed chimeric antigen receptor engineered T-cells (Icell Gene) CD4CAR (Icell Gene) 临床一期 Stony Brook University School Of Medicine, 归气丹生物医药(香港)有限公司, 刘易斯维尔大学 T-细胞淋巴瘤, T-细胞白血病 详情
VRC-HIVMAB091-00-AB N6LS; Z258‐N6LS; VRC-HIVMAB091-00-AB 临床二期 National Institute Of Allergy And Infectious Diseases (Niaid) HIV感染 详情
SCRI-E2CAR_EGFRtv1 SCRI-E2CAR_EGFRtv1 临床一期 Umoja BioPharma Inc 骨肉瘤 详情
Semzuvolimab dB4; UB-421; mAb-B4 临床三期 联合生物医药公司 HIV感染 详情
LB-1901 LB-1901; LB1901 临床一期 南京传奇生物科技有限公司 周围T-细胞淋巴瘤, T-细胞淋巴瘤, 皮肤T细胞淋巴瘤 详情
Tregalizumab hB-F5; BT-061 临床二期 Biotest Pharma Gmbh 药物超敏反应, 类风湿关节炎, 银屑病, 哮喘 详情
Autologous Regulatory Т-cell Therapy 临床二期 Institute Of Biophysics And Cell Engineering Of National Academy Of Sciences Of Belarus 系统性硬皮病 详情
CD4 CAR T cell therapy (iCell Gene Therapeutics) 临床一期 归气丹生物医药(香港)有限公司 T-细胞淋巴瘤 详情
CD4^LVFOXP3 Treg-like cell therapy CD4^LVFOXP3 临床一期 斯坦福大学 自身免疫性多内分泌腺病 详情
VRC-HIVMAB060-00-AB VRC-HIVMAB060-00-AB; VRC01 临床一期 National Institute Of Allergy And Infectious Diseases (Niaid) HIV感染 详情
ITV 1(Nonindustrial source) ITV-1 临床三期 Synexa Life Sciences, Immunotech Laboratories, Nonindustrial Source HIV感染 详情

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