Recombinant Proteins iso9001 ISO13485
 > 【CD4】重组蛋白信息


英文名称:T-cell surface antigen CD4
靶点别称:CD4mut,CD4 Antigens,T-cell surface antigen T4/Leu-3,T-cell surface glycoprotein CD4,CD4,CD4 Molecule,CD4 Antigen (P55),CD4 Receptor,CD4 Antigen

CD4 Molecule Synonym Name


CD4 分子背景

Cluster of Differentiation 4 (CD4) is also known as T-cell surface antigen T4/Leu-3 (LEU-3) and CD4mut, is a single-pass type I  membrane glycoprotein,and is a member of the immunoglobulin superfamily. CD4 expressed on the surface of T helper cells, monocytes, macrophages, and dendritic cells. It has four immunoglobulin domains (D1 to D4) that are exposed on the extracellular surface of the cell: D1 and D3 resemble immunoglobulin variable (IgV) domains. D2 and D4 resemble immunoglobulin constant (IgC) domains. CD4 is a co-receptor that assists the T cell receptor (TCR) with an antigen-presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR by recruiting an enzyme, known as the tyrosine kinase lck, which is essential for activating many molecules involved in the signaling cascade of an activated T cell. CD4 also interacts directly with MHC class II molecules on the surface of the antigen-presenting cell using its extracellular domain. The extracellular domain adopts an immunoglobulin-like beta-sandwich with seven strands in 2 beta sheets, in a Greek key topology. CD4 has also been shown to interact with SPG21, Lck and Protein unc-119 homolog. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.

CD4 参考文献


英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Ibalizumab-uiyk 5AB; Hu5A8; TMB-355; TNX-355 批准上市 百健 Trogarzo EU HIV感染 Theratechnologies Europe Ltd 2018-03-06 HIV感染 详情


英文名称 研发代码 研发阶段 公司 适应症 临床试验
IT-1208 (Kyowa Hakko Kirin) IT-1208 临床一期 协和发酵麒麟株式会社 肿瘤 详情
LCAR-T2C CAR-T cell therapy (Nanjing Medical University) 临床一期 南京医科大学附属第一医院 T-细胞淋巴瘤 详情
BG-8962 BG-8962 临床一期 国家过敏和传染病研究所 HIV感染 详情
T-allo-10 T-allo-10 临床一期 斯坦福大学 移植物抗宿主病 详情
ITV 1(Nonindustrial source) ITV-1 临床三期 Synexa Life Sciences, Immunotech Laboratories, Nonindustrial Source HIV感染 详情
CD4-directed chimeric antigen receptor engineered T-cells (Stony Brook University) CD4CAR 临床一期 Stony Brook University School Of Medicine, Icell Gene Therapeutics, 刘易斯维尔大学 白血病, T-细胞淋巴瘤 详情
Anti-CD4 CAR T-cell therapy (University of Pennsylvania) CAR-C34ZFN 临床一期 宾夕法尼亚大学 HIV感染 详情
VRC-07-523 VRC-07-523; VRC-07-523-L S; VRC-HIVMAB075-00-AB; VRC-HIVMAB-075 -00-AB 临床一期 美国国立卫生研究院 HIV感染 详情
MVA-EL MVA-EBNA1/LMP2 临床二期 香港中文大学, Cancer Research Uk 鼻咽肿瘤 详情
Tregalizumab hB-F5; BT-061 临床二期 Biotest Pharma Gmbh 药物超敏反应, 类风湿关节炎, 银屑病, 哮喘 详情
EC-18 EC-18 临床二期 Enzychem Lifesciences 中性粒细胞减少, 新型冠状病毒肺炎, 口腔炎, 发热性中性粒细胞减少症 详情
VRC-HIVAAV070-00-GT AAV8-VRC07 临床一期 国家过敏和传染病研究所 HIV感染 详情
Anti-CD3 anti-CD20 bispecific antibody (Genmab) GEN-3013 临床二期 Genmab 血液肿瘤 详情
VRC-01-LS VRC-01-LS; VRC-HIVMAB-080-00-AB 临床一期 国家过敏和传染病研究所 HIV感染 详情
CALRLong36 peptide (Herlev Hospital) 临床一期 Herlev Hospital 骨��增生性疾病 详情
VRC-HIVMAB091-00-AB N6LS; Z258‐N6LS; VRC-HIVMAB091-00-AB 临床一期 国家过敏和传染病研究所 HIV感染 详情
LB-1901 LB-1901; LB1901 临床一期 周围T-细胞淋巴瘤, T-细胞淋巴瘤, 皮肤T细胞淋巴瘤 详情
CD4 CAR T cell therapy (iCell Gene Therapeutics) 临床一期 Icell Gene Therapeutics T-细胞淋巴瘤 详情
GEN-009 GEN-009 临床二期 Genocea Biosciences 皮肤黑色素瘤, 肾细胞癌, 头颈部鳞状细胞癌, 移行细胞癌, 非小细胞肺癌 详情
RB-0003 RB-0003; BNT-111 临床二期 Biontech Se, Tron 黑色素瘤 详情
Anti-CD4 CAR-T (Legend) 临床一期 T-细胞淋巴瘤 详情
TMB-365 TMB-365 临床一期 中裕新药 HIV感染 详情
UB-421 dB4; UB-421; mAb-B4 临床三期 联合生物医药公司 HIV感染 详情