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CD36信息

英文名称:Platelet glycoprotein 4
中文名称:血小板糖蛋白4
靶点别称:CD36 Molecule,GP3B,GPIV,FAT,GP4,CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor),CD36 Molecule (Thrombospondin Receptor),Leukocyte Differentiation Antigen CD36,Platelet Glycoprotein IV,Platelet Glycoprotein 4,Fatty Acid Translocase,Glycoprotein IIIb,SCARB3,GPIIIB,PAS IV,Scavenger Receptor Class B, Member 3,Platelet Collagen Receptor,Thrombospondin Receptor,Cluster Determinant 36,PAS-4 Protein,CD36 Antigen,BDPLT10,CHDS7,PASIV,PAS-4
上市药物数量:0
临床药物数量:0
最高研发阶段:临床前

CD36产品列表

 
评论(2)
CD6-H5221|Human CD36 / SR-B3 Protein, His Tag (MALS verified)
  1. 166XXXXXXX7
  2. 1人赞
  3. CD36/SR-B3蛋白,带his标签,亲和力实验亲和力强,我们实验一次通过成功率高,有利于研发项目进展顺利推进。
  4. 2022-05-19
CD6-H82E9|Biotinylated Human CD36 / SR-B3 Protein, His,Avitag™
  1. 178XXXXXXX2
  2. 0人赞
  3. 该蛋白使用方便,易于保存,使用过程中一切正常,未发现有问题。客服态度很好,运输快,发货快。很好的购物体验。以后还会购买。
  4. 2022-11-10
 

CD36 分子别名

CD36,SCARB3,BDPLT10,CHDS7,FAT,GP3B,GP4,GPIV,PASIV,Platelet Glycoprotein 4,glycoprotein IV,gpIV,glycoprotein IIIb,gpIIIb

CD36 分子背景

CD36 (Cluster of Differentiation 36) is also known as platelet membrane glycoprotein IV (GPIV), fatty acid translocase (FAT), thrombospondin receptor, collagen receptor, and scavenger receptor class B, member 3 (SRB3), is a member of the class B scavenger receptor family of cell surface proteins. The human CD36 gene encodes a single chain 472 amino acid residue protein containing both an N- and a C-terminal cytoplasmic tail and an extracellular loop.CD36 is found on platelets, erythrocytes, monocytes, differentiated adipocytes, mammary epithelial cells, spleen cells and some skin microdermal endothelial cells. CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands, including long chain fatty acid (LCFA), advanced glycation end products (AGE), thrombospondin-1, oxidized low-density lipoproteins (oxLDLs), high density lipoprotein (HDL), phosphatidylserine, apoptotic cells, beta-amyloid fibrils (fAβ), collagens I and IV, and Plasmodium falciparum infected erythrocytes. CD36 is required for the anti-angiogenic effects of thrombospondin1 In the corneal neovascularization assay. On binding a ligand the protein and ligand are internalized. This internalization is independent of macropinocytosis and occurs by an actin dependent mechanism requiring the activation Src-family kinases, JNK and Rho-family GTPases. CD36 ligands have also been shown to promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

CD36 前沿进展

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