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Catenin beta-1信息

英文名称:Catenin beta 1
中文名称:连环素β1
靶点别称:NEDSDV,OK/SW-cl.35,CTNNB1,PRO2286,Catenin Beta 1,Catenin (Cadherin-Associated Protein), Beta 1, 88kDa,CTNNB,Catenin (Cadherin-Associated Protein), Beta 1 (88kD),Catenin (Cadherin-Associated Protein), Beta 1,Catenin Beta-1,Beta-Catenin,Armadillo,MRD19,EVR7,beta Catenin,β-Catenin
上市药物数量:0
临床药物数量:7
最高研发阶段:临床二期

Catenin beta-1分子别名

CTNNB, EVR7, MRD19, NEDSDV, armadillo

Catenin beta-1分子背景

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling.

Catenin beta-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
VTX-003 肿瘤 详情
CEQ-508 CEQ-508 临床二期 Marina Biotech 家族性腺瘤性息肉 详情
Foscenvivint PRI-724; ICG-001; OP-724 临床二期 南加州大学, Prism Pharma Co Ltd 慢性髓细胞白血病, 胆汁性肝硬化, 实体瘤, 胰腺癌, 肝硬化, 乙型肝炎, 丙型肝炎, 结直肠癌, 急性髓细胞样白血病 详情
Tegatrabetan BC-2059; APL-121 临床二期 艾尔建 尤因肉瘤, 纤维瘤, 黑色素瘤, 非小细胞肺癌, 肝细胞癌, 胰腺导管癌, 子宫内膜癌, 非霍奇金淋巴瘤, 肺癌, 结直肠癌, 神经母细胞瘤, 实体瘤, 骨肉瘤, 弥漫性大B-细胞淋巴瘤, 肿瘤, 胰腺癌, 卵巢上皮癌, 肾母细胞瘤, 肝胚细胞瘤, B-细胞淋巴瘤, 侵袭性纤维瘤病, 白血病 详情
E-7386 E-7386 临床二期 Prism Pharma Co Ltd, 卫材株式会社 肝癌, 实体瘤, 肿瘤, 结直肠癌, 子宫内膜癌, 黑色素瘤, 肝细胞癌, 胃肠道癌症 详情
CWP-232291 CWP-291; CWP-232291 临床二期 Jw Pharmaceutical Corp 慢性骨髓单核细胞性白血病, 骨髓增生异常综合征, 多发性骨髓瘤, 骨髓纤维化, 急性髓细胞样白血病 详情
ST-316 ST-316 临床一期 Sapience Therapeutics Inc 血液肿瘤, 实体瘤, 卵巢癌, 结肠癌, 胰腺癌, 皮肤肿瘤, 三阴性乳腺癌, 滑膜肉瘤, 乳腺癌, 胆管上皮癌, 非小细胞肺癌, 黑色素瘤, 肝细胞癌 详情
FOG-001 FOG-001 临床二期 哈佛大学, Fog Pharmaceutical Inc 家族性腺瘤性息肉, 实体瘤, 食道癌, 胃癌, 肿瘤, 消化系统肿瘤, 结直肠癌, 胃肠道癌症, 非小细胞肺癌, 转移癌 详情

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