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CD28信息

英文名称:T-cell-specific surface glycoprotein CD28
中文名称:T细胞特异性表面糖蛋白CD28
靶点别称:CD28,CD28 Antigen,T-Cell-Specific Surface Glycoprotein CD28,CD28 Antigen (Tp44),Tp44,CD28 Antigens,CD28 Molecule,T-Cell-Specific Surface Glycoprotein
上市药物数量:0
临床药物数量:13
最高研发阶段:临床二期

CD28产品列表

 
评论(7)
CD8-H52Hc|Human / Cynomolgus / Rhesus macaque CD28 Protein, His Tag, active dimer (MALS verified)
  1. 156XXXXXXX8
  2. 6人赞
  3. 在ELISA结合上,能够与CD80结合,能够获得较好的拟合曲线,获得较好的EC50值,且实验结果可重复
  4. 2020-10-09
CD8-H52Hc|Human / Cynomolgus / Rhesus macaque CD28 Protein, His Tag, active dimer (MALS verified)
  1. 139XXXXXXX3
  2. 3人赞
  3. 用于抗体筛选工作,抗原包被效果良好,目前实验顺利进行中,提供的技术支持也比较完善,试验中出现的问题都能给予多方面的支持
  4. >
  5. 2021-11-11
CD8-H52A5|Human / Cynomolgus / Rhesus macaque CD28 Protein, Mouse IgG2a Fc Tag (MALS verified)
  1. 156XXXXXXX8
  2. 3人赞
  3. 在ELISA结合上,既能与人的CD80结合,又能结合鼠的CD80, 能够获得较好的拟合曲线,且实验结果可重复,EC50值与产品描述基本一致
  4. 2020-10-09
 

Synonym Name

CD28,Tp44

Background

T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.

Clinical and Translational Updates

CD28临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells (City of Hope Medical Center) 临床一期 希望之城国家医疗中心 非霍奇金淋巴瘤 详情
B7-2/GM-CSF cancer gene therapy CIT 临床一期 Radient 肿瘤 详情
InHeAb-01 InHeAb-01; bsAB 临床阶段不明 肿瘤 详情
CD19 PD-1/CD28 CAR-T Cell Therapy (Second Affiliated Hospital School Of Zhejiang University School Of Medicine) 临床一期 浙江大学医学院附属第二医院 B-细胞淋巴瘤, 弥漫性大B-细胞淋巴瘤, 滤泡中心淋巴瘤, 套细胞淋巴瘤, 原发性纵隔B细胞淋巴瘤 详情
CC-312 CC-312 临床一期 详情
Abatacept (Orban Biotech) 临床二期 Orban Biotech, 国家糖尿病消化与肾脏病研究院 一型糖尿病 详情
Theralizumab TAB-08; TABO-8 Theramab 详情
FPT-155 CD80-Fc; FPT-155 Five Prime Therapeutics Inc 详情
REGN-5668 REGN-5668 Regeneron Pharmaceuticals 详情
REGN-7075 REGN-7075 Regeneron Pharmaceuticals 详情
SAR-443216 SAR-443216 赛诺菲 详情
REGN-5678 REGN-5678 Regeneron Pharmaceuticals Inc 详情
Reltecimod P2-TA; AB-103 Atox Bio 详情
Davoceticept ALPN-202 Alpine Immune Sciences 详情
Acazicolcept ALPN-101 临床二期 Alpine Immune Sciences, 艾伯维 移植物抗宿主病, 自身免疫疾病, 系统性红斑狼疮, X-连锁淋巴增生症, 炎性疾病 详情
TC-510 TC-510 临床二期 Tcr2 Therapeutics 卵巢癌, 实体瘤, 胰腺癌, 三阴性乳腺肿瘤, 间皮组织肿瘤, 结直肠癌, 腺癌 详情
FR-104 FR-104; JNJ-3133; VEL-101 临床二期 Effimune 肾脏移植排斥, 类风湿关节炎, 术后并发症 详情
SAR-442257 SAR-442257 临床一期 赛诺菲 肿瘤 详情
Lulizumab pegol Lulizumab; BMS-931699 临床二期 百时美施贵宝 寻常狼疮, 肾脏移植排斥, Sjogren-Larsson综合征 详情

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