CD28 靶点蛋白|抗体药物|临床药物信息

CD28信息

英文名称：T-cell-specific surface glycoprotein CD28
中文名称：T细胞特异性表面糖蛋白CD28
靶点别称：CD28，CD28 Antigen，T-Cell-Specific Surface Glycoprotein CD28，CD28 Antigen (Tp44)，Tp44，CD28 Antigens，CD28 Molecule，T-Cell-Specific Surface Glycoprotein

上市药物数量：0
临床药物数量：20
最高研发阶段：临床二期

CD28产品列表

筛选结果

产品库

在线 (14)

物种

标签

属性

标记

货号	物种	产品描述
CD8-H52Hc	Human / Cynomolgus / Rhesus macaque	Human / Cynomolgus / Rhesus macaque CD28 Protein, His Tag, active dimer (MALS verified)
CD8-H82F2	Human / Cynomolgus / Rhesus macaque	Biotinylated Human / Cynomolgus / Rhesus macaque CD28 Protein, Fc,Avitag™, active dimer (MALS verified)
CD8-M52H6	Mouse	Mouse CD28 Protein, His Tag, active dimer (MALS verified)
CD8-M120b	Mouse	Monoclonal Anti-Human CD28 Antibody, premium grade
CD8-H52A5	Human / Cynomolgus / Rhesus macaque	Human / Cynomolgus / Rhesus macaque CD28 Protein, Mouse IgG2a Fc Tag (MALS verified)
CD8-H525a	Human / Cynomolgus / Rhesus macaque	Human / Cynomolgus / Rhesus macaque CD28 Protein, Fc Tag, active dimer (MALS verified)
CD8-H82E5	Human / Cynomolgus / Rhesus macaque	Biotinylated Human / Cynomolgus / Rhesus macaque CD28 Protein, His,Avitag™, active dimer (MALS verified)
CD8-M82E3	Mouse	Biotinylated Mouse CD28 Protein, His,Avitag™, active dimer (MALS verified)
CD8-M5258	Mouse	Mouse CD28 Protein, Fc Tag (MALS verified)
CD8-R52H9	Rat	Rat CD28 Protein, His Tag (BLI verified)
CD8-BM225	Mouse	Biotinylated Anti-Human CD28 Antibody, Mouse IgG1,Avitag™, premium grade
GMP-MC2824	Mouse	GMP Monoclonal Anti-Human CD28 Antibody DMF Filed
EP-150	Human	CD28 : B7-1 [Biotinylated] Inhibitor Screening ELISA Kit
EP-151	Human	CD28 : B7-2 [Biotinylated] Inhibitor Screening ELISA Kit

CD8-H52Hc|Human / Cynomolgus / Rhesus macaque CD28 Protein, His Tag, active dimer (MALS verified)

156XXXXXXX8

6人赞

在ELISA结合上，能够与CD80结合，能够获得较好的拟合曲线，获得较好的EC50值，且实验结果可重复
2020-10-09

CD8-H52Hc|Human / Cynomolgus / Rhesus macaque CD28 Protein, His Tag, active dimer (MALS verified)

139XXXXXXX3

3人赞

用于抗体筛选工作，抗原包被效果良好，目前实验顺利进行中，提供的技术支持也比较完善，试验中出现的问题都能给予多方面的支持
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2021-11-11

CD8-H52A5|Human / Cynomolgus / Rhesus macaque CD28 Protein, Mouse IgG2a Fc Tag (MALS verified)

156XXXXXXX8

3人赞

在ELISA结合上，既能与人的CD80结合，又能结合鼠的CD80, 能够获得较好的拟合曲线，且实验结果可重复，EC50值与产品描述基本一致
2020-10-09

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Synonym Name

CD28,Tp44

Background

T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.

Clinical and Translational Updates

CD28临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
TC-510	TC-510	临床二期	Tcr2 Therapeutics Inc	实体瘤, 卵巢癌, 三阴性乳腺癌, 胰腺癌, 间皮组织肿瘤, 结直肠癌, 腺癌	详情
REGN-7075	REGN-7075	临床二期	Regeneron Pharmaceuticals Inc	实体瘤, 肿瘤	详情
REGN-5668	REGN-5668	临床二期	Regeneron Pharmaceuticals Inc	卵巢癌, 腹膜癌, 输卵管癌	详情
REGN-5678	REGN-5678	临床二期	Regeneron Pharmaceuticals Inc	去势抵抗性前列腺肿瘤	详情
RG-6333	RO-7443904	临床一期	F. Hoffmann-La Roche Ag	非霍奇金淋巴瘤	详情
Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells (City of Hope Medical Center)		临床一期	希望之城国家医疗中心	非霍奇金淋巴瘤	详情
SAR-443216	SAR-443216	临床一期	赛诺菲	胃癌, 肿瘤, 乳腺癌, 肺癌	详情
Abatacept (Orban Biotech)		临床二期	Orban Biotech, 国家糖尿病消化与肾脏病研究院	一型糖尿病	详情
Lulizumab pegol	Lulizumab; BMS-931699	临床二期	百时美施贵宝	肾脏移植排斥, 寻常狼疮, Sjogren-Larsson综合征	详情
ATLCAR.k.CD28 cells (UNC Lineberger Comprehensive Cancer Center)		临床一期	Unc Lineberger Comprehensive Cancer Center	边缘带B细胞淋巴瘤, 滤泡中心淋巴瘤, 套细胞淋巴瘤, 非霍奇金淋巴瘤, 淋巴瘤	详情
FPT-155	CD80-Fc; FPT-155	临床一期	Five Prime Therapeutics Inc	实体瘤, 肿瘤	详情
Davoceticept	ALPN-202	临床一期	Alpine Immune Sciences Inc	实体瘤, 淋巴瘤	详情
CD19 PD-1/CD28 CAR-T Cell Therapy (Second Affiliated Hospital School Of Zhejiang University School Of Medicine)		临床一期	浙江大学医学院附属第二医院	B-细胞淋巴瘤, 弥漫性大B-细胞淋巴瘤, 滤泡中心淋巴瘤, 套细胞淋巴瘤, 原发性纵隔B细胞淋巴瘤	详情
XmAb-808	XmAb808	临床一期	Xencor Inc	肾细胞癌, 头颈部鳞状细胞癌, 三阴性乳腺癌, 卵巢上皮癌, 尿路上皮癌, 去势抵抗性前列腺肿瘤, 前列腺癌, 结直肠癌, 非小细胞肺癌, 黑色素瘤	详情
FR-104	FR-104; JNJ-3133; VEL-101	临床二期	Effimune	肾脏移植排斥, 类风湿关节炎, 术后并发症	详情
CC-312	CC-312	临床一期	惠和生物技术（上海）有限公司		详情
B7-2/GM-CSF cancer gene therapy	CIT	临床一期	Radient	肿瘤	详情
InHeAb-01	InHeAb-01; bsAB	临床阶段不明	University Hospital Tuebingen	肿瘤	详情
SAR-442257	SAR-442257	临床一期	赛诺菲	肿瘤	详情
Acazicolcept	ALPN-101	临床二期	Alpine Immune Sciences Inc, 艾伯维	移植物抗宿主病, 自身免疫疾病, 系统性红斑狼疮, X-连锁淋巴增生症, 炎性疾病	详情

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CD28