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CD27 Ligand信息

英文名称:CD70 antigen
中文名称:CD70抗原
靶点别称:LPFS3,CD27L,Tumor necrosis factor ligand superfamily member 7,CD27LG,CD27-L,CD70,CD70 Molecule,TNFSF7,Tumor Necrosis Factor (Ligand) Superfamily, Member 7,Tumor Necrosis Factor Ligand 8A,Ki-24 Antigen,TNLG8A,CD27 Ligand,CD70 antigen,Surface Antigen CD70
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

CD27 Ligand 分子别名

CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

CD27 Ligand 分子背景

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

CD27 Ligand 前沿进展

CD27 Ligand临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
CTX-130 CTX-130 临床一期 Crispr Therapeutics 血液肿瘤, 肾细胞癌, T-细胞淋巴瘤 详情
Cusatuzumab ARGX-110; JNJ-4550 临床二期 Argen-X 血液肿瘤, 肿瘤, 骨髓增生异常综合征, 慢性骨髓单核细胞性白血病, 急性髓细胞样白血病, 皮肤T细胞淋巴瘤 详情
SEA-CD70 SEA-CD70 临床一期 Seattle Genetics Inc 骨髓增生异常综合征, 急性髓细胞样白血病 详情

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