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 > 【CD27 Ligand】

CD27 Ligand信息

英文名称:CD70 antigen
中文名称:CD70抗原
靶点别称:CD70 antigen,Surface Antigen CD70,LPFS3,CD27L,Tumor necrosis factor ligand superfamily member 7,CD27LG,CD27-L,CD70,CD70 Molecule,TNFSF7,Tumor Necrosis Factor (Ligand) Superfamily, Member 7,Tumor Necrosis Factor Ligand 8A,Ki-24 Antigen,TNLG8A,CD27 Ligand
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

CD27 Ligand产品列表

 
评论(4)
CDL-H52Da|Human CD27 Ligand / CD70 Protein, His,Flag Tag (active trimer) (MALS verified)
  1. 188XXXXXXX4
  2. 4人赞
  3. 产品质量稳定可靠,实验结果重复性比较好,而且产品包装也不错,总体来说使用起来还挺好的,也比较省心,产品的标签或者说明也挺清晰的
  4. 2022-03-01
CDL-H52Da|Human CD27 Ligand / CD70 Protein, His,Flag Tag (active trimer) (MALS verified)
  1. 136XXXXXXX5
  2. 3人赞
  3. CD70这一款抗原可以特异性的结合我们的抗体,EC50比较稳定,曲线可以呈现出比较好的线性,没有非特异的结合!使用起来还是非常好的☀️
  4. 2021-12-15
CDD-HF2D4|FITC-Labeled Human CD27 Ligand / CD70 Protein, His,Flag Tag active trimer (MALS verified)
  1. 150XXXXXXX0
  2. 0人赞
  3. 检测效果不错,FITC标签荧光强度正好
  4. >
  5. 2022-10-10
 

CD27 Ligand 分子别名

CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

CD27 Ligand 分子背景

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

CD27 Ligand 前沿进展

CD27 Ligand临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
CD19/70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) 临床二期 深圳市免疫基因治疗研究院 B-细胞淋巴瘤 详情
PSMA/CD70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) bi-4SCAR PSMA/CD70 临床二期 深圳市免疫基因治疗研究院 肿瘤 详情
AMG-172 AMG-172 安进 详情
C-4-29 临床一期 重庆精准生物技术有限公司 肾细胞癌, 多发性骨髓瘤 详情
ALLO-316 ALLO-316 Allogene Therapeutics Inc 详情
MDX-1203 BMS-936561; MDX-1203 百时美施贵宝 详情
SEA-CD70 SEA-CD70 临床一期 Seattle Genetics Inc 急性髓细胞样白血病 详情
iHIVARNA-01 iHIVARNA-01 Idibaps 详情
Vorsetuzumab mafodotin SGN-75 Seattle Genetics Inc 详情
GD2/CD70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) bi-4SCAR GD2/CD70 临床二期 深圳市免疫基因治疗研究院 肿瘤 详情
ARX-305 ARX-305; NCB-002 临床一期 Ambrx Inc, 浙江新码生物医药有限公司 肿瘤 详情
CTX-130 CTX-130 临床一期 Crispr Therapeutics 肾细胞癌, T-细胞淋巴瘤 详情
Cusatuzumab ARGX-110; JNJ-4550 临床二期 Argenx Se 骨髓增生异常综合征, 慢性骨髓单核细胞性白血病, 肿瘤, 急性髓细胞样白血病 详情
CD70 CAR-T cell therapy (Chongqing Precision Biotech) 临床一期 重庆精准生物技术有限公司 卵巢癌, 实体瘤, 肾细胞癌, 肿瘤, 宫颈癌, 转移癌 详情

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