CD27 靶点蛋白|抗体药物|临床药物信息

CD27信息

英文名称：CD27 antigen
中文名称：CD27抗原
靶点别称：CD27 antigen，Tumor necrosis factor receptor superfamily member 7，CD27L receptor，CD27，CD27 Molecule，T-Cell Activation Antigen CD27，TNFRSF7，T14，T Cell Activation Antigen S152，S152. LPFS2，S152，Tp55，Tumor Necrosis Factor Receptor Superfamily， Member 7

上市药物数量：0
临床药物数量：4
最高研发阶段：临床二期

CD27产品列表

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在线 (8)

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货号	物种	产品描述
CD7-H522b	Human	Human CD27 / TNFRSF7 Protein, His Tag
TN7-H82F6	Human	Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag™
CD7-H5254	Human	Human CD27 / TNFRSF7 Protein, Fc Tag (HPLC verified)
CD7-C5259	Cynomolgus / Rhesus macaque	Cynomolgus / Rhesus macaque CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H5257	Human	Human CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-M5252	Mouse	Mouse CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-R52H9	Rat	Rat CD27 / TNFRSF7 Protein, His Tag
EP-121	Human	CD27L [Biotinylated] : CD27 Inhibitor Screening ELISA Kit

TN7-H82F6|Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag™

188XXXXXXX9

0人赞

The antigen was purchased for phage screening antibody, and after experimental verification, a good screening positive result was obtained. Also used for BLI analysis, human monoclonal antibodies loaded on humanFc biosensors can effectively bind. On elisa blocking assay, the background is very clean compared with another similar product, and this protein used for subsequent screening has obtained the lead
2023-04-14

CD7-H5254|Human CD27 / TNFRSF7 Protein, Fc Tag (HPLC verified)

139XXXXXXX3

0人赞

使用百普赛斯的蛋白进行大分子之间的相互作用，可以取得较好的实验效果，拥有批间差异小，实验重复性好的优点，值得信赖
2022-06-25

CD27分子别名

CD27,TNFRSF7,S152,T14,Tp55

CD27分子背景

CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

CD27临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Anti-CD27 monoclonal antibody (Aduro Biotech)	BION-1402	临床一期	Aduro Biotech Inc	肿瘤	详情
Boserolimab	MK-5890	临床二期	Merck & Co Inc	实体瘤, 小细胞肺癌, 三阴性乳腺癌, 非小细胞肺癌	详情
Varlilumab	CDX-1127	临床二期	Celldex Therapeutics	肺癌, 胆管上皮癌, 浆母细胞淋巴瘤, 原发性渗出性淋巴瘤, 原发性纵隔B细胞淋巴瘤, 星形细胞瘤, 胆道癌, 泌尿系肿瘤, 淋巴瘤, 胶质瘤, 前列腺癌, 胆囊癌, T-细胞淋巴瘤, Burkitt淋巴瘤, 非霍奇金淋巴瘤, 泌尿生殖道肿瘤, 非小细胞肺癌, 慢性淋巴细胞白血病, 腺癌, 黑色素瘤, 皮肤肿瘤, 实体瘤, 卵巢癌, 胆管癌, 肾肿瘤, 头颈癌, 头颈部鳞状细胞癌, 肾细胞癌, 肿瘤, 弥漫性大B-细胞淋巴瘤, B-细胞淋巴瘤, 淋巴瘤样肉芽肿病, 复合性淋巴瘤, 肾脏疾病, 三阴性乳腺癌, 胶质母细胞瘤, 少突神经胶质瘤, 膀胱癌, 泌尿系疾病, 套细胞淋巴瘤	详情
LOR-S03	CDX-527	临床一期	Celldex Therapeutics	实体瘤, 肝癌, 卵巢癌, 头颈癌, 胃癌, 肾细胞癌, 食道癌, 肿瘤, 高微卫星不稳定性癌症, 膀胱癌, 乳腺癌, 胆管上皮癌, 结直肠癌, 腹膜癌, 输卵管癌, 非小细胞肺癌	详情

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