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CD23信息

英文名称:Immunoglobulin epsilon Fc receptor
中文名称:免疫球蛋白ε-Fc受体
靶点别称:Low affinity immunoglobulin epsilon Fc receptor,FCE2,CD23A,FCER2,CLEC4J,BLAST-2,Fc Fragment Of IgE Receptor II,C-Type Lectin Domain Family 4, Member J,Immunoglobulin Epsilon-Chain,CD23,Lymphocyte IgE Receptor,Fc Epsilon Receptor II,Fc-Epsilon-RII,CD23 Antigen,IGEBF,Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23A),C-Type Lectin Domain Family 4 Member J,Immunoglobulin E-binding factor,Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23)
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

CD23产品列表

 
评论(1)
CD3-H5249|Human CD23 / Fc epsilon RII Protein, His Tag (MALS verified)
  1. 139XXXXXXX3
  2. 1人赞
  3. 我们实验室的蛋白用于后插脂质体,筛选偶联条件。并通过胶图观察是否偶联成功。筛选过程虽然较久,但是结果很赞。蛋白稳定性也很好。
  4. 2022-03-17
 

CD23 分子别名

FCER2,CD23,CD23A,CLEC4J,FCE2,IGEBF,FcεRII,FcεRⅡ

CD23 分子背景

Cluster of differentiation 23 (CD23) is also known as Low affinity immunoglobulin epsilon Fc receptor (FCER2), C-type lectin domain family 4 member J (CLEC4J), Fc-epsilon-RII (FcεRII), Immunoglobulin E-binding factor (IGEBF), is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets.There are two forms of CD23: CD23a and CD23b. CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages. CD23 is known to have role of transportation in antibody feedback regulation. Antigen that enters the blood stream is captured by antigen specific IgE antibodies. The IgE immune complexes that are formed bind to CD23 molecules on B cells, and are transported to the B cell follicles of the spleen. The antigen is then transferred from CD23+ B cells to CD11c+ antigen presenting cells. The CD11c+ cells in turn present the antigen to CD4+ T cells, which can lead to an enhanced antibody response. In flow cytometry, CD23 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) from mantle cell leukemia (CD23-negative).

CD23 前沿进展

CD23临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
RO-7297089 RO-7297089; AFM-26; RG-6296 临床一期 基因泰克 多发性骨髓瘤 详情

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