登录 | 注册    关注公众号  
微信公众号
搜索
 > 【CD14】

CD14信息

英文名称:Monocyte differentiation antigen CD14
中文名称:单核细胞分化抗原CD14
靶点别称:CD14,CD14 Molecule,Myeloid Cell-Specific Leucine-Rich Glycoprotein,CD14 Antigen,Monocyte Differentiation Antigen CD14
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

CD14 分子别名

CD14

CD14 分子背景

Cluster of differentiation 14 (CD14), is a cell surface glycoprotein, and is a is a component of the innate immune system. CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa). CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP). CD14 has been proposed to be involved in various biological processes, including transportation of other lipids, cell-cell interaction during different immune responses, as well as recognition of apoptotic cells. Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns. CD14+ cells are monocytes that can differentiate into a host of different cells. CD14 has been shown to interact with Lipopolysaccharide-binding protein.

CD14 前沿进展

CD14临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Atibuclimab IC-14 临床二期 Icos Corporation 运动神经元病, 肺炎, 脓毒病, 新型冠状病毒肺炎, 成人呼吸窘迫综合征, 肺疾病, 肌萎缩性侧索硬化, 登革热 详情

消息提示

请输入您的联系方式,再点击提交!

确定