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Cathepsin B信息

英文名称:Cathepsin B
中文名称:组织蛋白酶B
靶点别称:EC 3.4.22,EC:3.4.22.1,RECEUP,Cathepsin B,Amyloid Precursor Protein Secretase,Epididymis Secretory Sperm Binding Protein,Cathepsin B1,Cysteine Protease,EC 3.4.22.1,CPSB,APPS,APP secretase,CTSB
上市药物数量:0
临床药物数量:4
最高研发阶段:临床前

Cathepsin B产品列表

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评论(4)
CTB-H5222|Human Cathepsin B / CTSB Protein, His Tag (active enzyme, MALS verified)
  1. 181XXXXXXX0
  2. 2人赞
  3. 酶切linker效果很好,可实现较为高效和具有特异性的酶切作用,而且产品纯度比较高,稳定性好,实验的可重复性还挺好的,总之产品满意。
  4. 2022-03-18
CTB-H5222|Human Cathepsin B / CTSB Protein, His Tag (active enzyme, MALS verified)
  1. 178XXXXXXX2
  2. 1人赞
  3. 1样品很稳定,活性很好 2、样品蛋白容易溶解 3 活性好!4,存储稳定性特别好,非常好的感受 5 ,物流特别快,隔天到 6 多年的选择
  4. 2022-04-21
CTB-H5222|Human Cathepsin B / CTSB Protein, His Tag (active enzyme, MALS verified)
  1. 178XXXXXXX2
  2. 0人赞
  3. 这个试剂用于分析实验,活性很好!物流也是很快,包装也是很好!是你非常不错的选择。实验没有问题的,重复性也特别特别的好
  4. 2022-07-08
 

Cathepsin B 分子别名

CTSB,CPSB,APPS

Cathepsin B 分子背景

Cathepsin B (CTSB) is also known as APP secretase (APPS) and CPSB, is an enzymatic protein belonging to the peptidase C1 family. Cathepsin B / CTSB is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme. The catalytic activity of Cathepsin B / APPS contains: Hydrolysis of proteins with broad specificity for peptide bonds; Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L); In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. As a thiol protease, cathepsin B / CPSB is believed to participate in intracellular degradation and turnover of proteins and has also been implicated in tumor invasion and metastasis. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors.

Cathepsin B 前沿进展

Cathepsin B临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Osugacestat AL-101(BMS); BMS-906024 百时美施贵宝, 葛兰素史克 详情
EVP-0962 EVP-0962; EVP-0015962 Forum Pharmaceuticals 详情

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