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 > 【Cathepsin B】重组蛋白信息

Cathepsin B信息

英文名称:Cathepsin B
中文名称:组织蛋白酶B
靶点别称:CPSB,APPS,APP secretase,CTSB,Cathepsin B1,Cysteine Protease,EC 3.4.22.1,EC 3.4.22,RECEUP,EC:3.4.22.1,Epididymis Secretory Sperm Binding Protein,Cathepsin B,Amyloid Precursor Protein Secretase
上市药物数量:0
临床药物数量:3
最高研发阶段:临床三期

Cathepsin B产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
CTB-H5222
Human
Human Cathepsin B / CTSB Protein, His Tag
 
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Cathepsin B 分子别名

CTSB,CPSB,APPS

Cathepsin B 分子背景

Cathepsin B (CTSB) is also known as APP secretase (APPS) and CPSB, is an enzymatic protein belonging to the peptidase C1 family. Cathepsin B / CTSB is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme. The catalytic activity of Cathepsin B / APPS contains: Hydrolysis of proteins with broad specificity for peptide bonds; Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L); In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. As a thiol protease, cathepsin B / CPSB is believed to participate in intracellular degradation and turnover of proteins and has also been implicated in tumor invasion and metastasis. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors.

Cathepsin B 参考文献

Cathepsin B临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Aoxistatin AB-007; E-64-d 临床三期 Taisho Pharmaceutical Holdings Co Ltd 肌营养不良
AL-101 AL-101; BMS-906024 临床二期 百时美施贵宝 肿瘤, 三阴性乳腺肿瘤, 腺样囊性癌, 前体T-淋巴母细胞性淋巴瘤白血病 详情
VBY-376 VBY-376 临床一期 Virobay 非酒精性脂肪肝, 肝硬化, 慢性丙型肝炎 详情

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