Melanotransferrin 靶点蛋白|抗体药物|临床药物信息

Melanotransferrin信息

英文名称：Melanotransferrin
中文名称：黑素转铁蛋白
靶点别称：Melanoma-associated antigen p97，CD228，Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2 And 96.5，MAP97，Membrane-Bound Transferrin-Like Protein，MGC4856，MTF1，FLJ38863，CD228 Antigen，MTf，MFI2

上市药物数量：0
临床药物数量：2
最高研发阶段：临床一期

Melanotransferrin产品列表

筛选结果

产品库

在线 (1)

物种

Human (1)

标签

His Tag (1)

属性

Protein (1)

标记

Unconjugated (1)

货号	物种	产品描述	蛋白结构	纯度	活性
MEN-H5223	Human	Human Melanotransferrin / CD228 Protein, His Tag (MALS verified)

Melanotransferrin 分子别名

Melanotransferrin,CD228,MFI2,MAP97,MELTF

Melanotransferrin 分子背景

Melanotransferrin (MTF), also known as CD228, P97, MELTF and MFI2, is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. MTF expression is low in normal tissues but high in tumor and embryonic tissues. In melanoma MTF is associated with tumor metastasis and angiogenesis and upregulated in lung cancer tissue and cell lines. In the brain MTF is expressed in capillary endothelium but also in the reactive microglia associated with senile plaques in Alzheimer's disease (AD).

Melanotransferrin 前沿进展

Melanotransferrin临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
SGN-CD228A	SGN-CD228A	临床一期	Seattle Genetics Inc	皮肤黑色素瘤, 间皮组织肿瘤, 乳腺癌, 结直肠癌, 胰腺导管癌, 非小细胞肺癌	详情
SGN-BB228	SGN-BB228	临床一期	Seagen Inc	皮肤黑色素瘤, 胰腺癌, 间皮组织肿瘤, 结直肠癌, 非小细胞肺癌	详情

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