KLRG1 靶点蛋白|抗体药物|临床药物信息

KLRG1信息

英文名称：Killer cell lectin-like receptor subfamily G member 1
中文名称：杀伤细胞凝集素样受体亚家族G成员1
靶点别称：C-type lectin domain family 15 member A，ITIM-containing receptor MAFA-L，MAFA-like receptor，Mast cell function-associated antigen，CLEC15A，MAFA，MAFAL

上市药物数量：0
临床药物数量：1
最高研发阶段：临床二期

KLRG1产品列表

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产品库

在线 (2)

物种

标签

His Tag (2)

属性

Protein (2)

标记

Unconjugated (2)

货号	物种	产品描述	蛋白结构	纯度	活性
KL1-M5249	Mouse	Mouse KLRG1 Protein, His Tag (MALS & SPR verified)
KL1-H5249	Human	Human KLRG1 Protein, His Tag (SPR verified)

KLRG1 分子别名

KLRG1

KLRG1 分子背景

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.

KLRG1 前沿进展

KLRG1临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
ABC-008		临床二期	Abcuro Inc	包涵体肌炎, 大颗粒淋巴细胞白血病	详情

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