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BMPR-IA信息

英文名称:Bone morphogenetic protein receptor type-1A
中文名称:1A型骨形态发生蛋白受体
靶点别称:Activin A Receptor, Type II-Like Kinase 3,CD292 Antigen,EC 2.7.11.30,10q23del,CD292,BMP type-1A receptor,ALK-3,Activin receptor-like kinase 3,Bone morphogenetic protein receptor type-1A,ALK3,BMPR1A,Bone Morphogenetic Protein Receptor, Type IA,Serine/Threo
上市药物数量:2
临床药物数量:0
最高研发阶段:批准上市

BMPR-IA产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
AL3-H5228
Human
Human BMPR-IA / ALK-3 Protein, His Tag
AL3-H5259
Human
Human ALK-3/BMPR1A Protein,with Fc Tag
 
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BMPR-IA 分子别名

BMPR-1A,ALK-3,10q23del,ACVRLK3,CD292,SKR5

BMPR-IA 分子背景

The bone morphogenetic protein receptor, type IA is also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2[1]. Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis.

BMPR-IA 前沿进展

BMPR-IA上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
DWP-431 DWP-431; rhBMP-2 批准上市 大熊制药株式会社 Novosis, Novosis-Dental South Korea 牙槽骨质丢失 Daewoong Pharmaceutical Co Ltd 2013-01-01 牙槽骨质丢失 详情
Dibotermin alfa YM-484; rhBMP-2/CPM 批准上市 美敦力 Inductos EU 胫骨骨折 Medtronic Biopharma Bv 2002-09-09 胫骨骨折, 骨损伤, 桡骨骨折, 骨关节炎 详情

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