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BAFF信息

英文名称:B-cell-activating factor/B lymphocyte stimulator
中文名称:B细胞活化因子/B淋巴细胞刺激因子
靶点别称:Dendritic Cell-Derived TNF-Like Molecule,B-Cell-Activating Factor,CD257,Epididymis Secretory Sperm Binding Protein,Tumor Necrosis Factor-Like Protein ZTNF4,Delta4 BAFF,BAFF,THANK,BLYS,ApoL Related Ligand TALL-1,TNF Superfamily Member 13b,Delta BAFF,TALL-1,Tumor Necrosis Factor Ligand 7A,B-Cell Activating Factor,B Lymphocyte Stimulator,B-Lymphocyte Stimulator,TNF And ApoL-Related Leukocyte Expressed Ligand 1,ZTNF4,Tumor Necrosis Factor (Ligand) Superfamily, Member 20,TNF- And APOL-Related Leukocy
上市药物数量:2
临床药物数量:3
最高研发阶段:批准上市

BAFF产品列表

 
评论(5)
BAF-H52D4|Human BAFF / TNFSF13B / CD257 Protein, His,Flag Tag, active trimer (MALS verified)
  1. 188XXXXXXX5
  2. 2人赞
  3. 采购该蛋白CD257 Protein,用于ELISA检测(受体配体亲和力/阻断活性筛选),我们用阳性对照,做了预实验结果不错,推荐使用。
  4. 2021-11-21
BAF-H52D4|Human BAFF / TNFSF13B / CD257 Protein, His,Flag Tag, active trimer (MALS verified)
  1. 188XXXXXXX6
  2. 1人赞
  3. 这个抗原是用来做elisa及测抗体亲和力用的,结果一直很稳定也符合预期,对筛选抗体很有帮助,极力推荐大家使用!
  4. 2021-11-10
BAF-H82Q2|Biotinylated Human BAFF / TNFSF13B / CD257 Protein, His,Avitag™ (active trimer) (MALS verified)
  1. 156XXXXXXX9
  2. 0人赞
  3. 一直都在用ACRO的产品,批间差异较小,而且供货速度快。我用这个产品进行中和抗体检测方法开发,目前方法验证已完成。仍然会持续使用ACRO产品。
  4. >
  5. 2021-10-21
 

BAFF 分子别名

TNFSF13B,BAFF,BLYS,CD257,DTL,TALL1,THANK,TNFSF20,ZTNF4,TALL-1

BAFF 分子背景

B-cell activating factor (BAFF) is also known as tumor necrosis factor ligand superfamily member 13B , TNFSF13B, BAFF, B Lymphocyte Stimulator (BLyS) , cluster of differentiation 257 (CD257), DTL, TNF- and APOL-related leukocyte expressed ligand (TALL-1), THANK, TNFSF20, ZTNF4, and is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. It is expressed as transmembrane protein on various cell types including monocytes, dendritic cells and bone marrow stromal cells. BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R, TACI, and BCMA, all of which have differing binding affinities for it. These receptors are expressed mainly on mature B lymphocytes (TACI is also found on a subset of T-cells and BCMA on plasma cells). TACI binds worst since its affinity is higher for a protein similar to BAFF, called a proliferation-inducing ligand (APRIL). BCMA displays an intermediate binding phenotype and will work with either BAFF or APRIL to varying degrees. Signaling through BAFF-R and BCMA stimulates B lymphocytes to undergo proliferation and to counter apoptosis. All these ligands act as heterotrimers (i.e. three of the same molecule) interacting with heterotrimeric receptors, although BAFF has been known to be active as either a hetero- or homotrimer. BAFF acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells. 

BAFF 前沿进展

BAFF上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Belimumab 贝利尤单抗 BmAb; HGS-1006; GSK-1550188 批准上市 葛兰素史克 Benlysta, 倍力腾 Mainland China 狼疮肾炎 Glaxosmithkline (China) Investment Co Ltd 2011-03-09 狼疮肾炎, 系统性红斑狼疮 详情
Telitacicept 泰它西普 RCT-18; RC-18; RCT18; RC18 批准上市 荣昌生物制药(烟台)股份有限公司 泰爱 Mainland China 系统性红斑狼疮 RemeGen Co Ltd 2021-03-09 重症肌无力, 复发-缓解型多发性硬化, 免疫球蛋白a肾病, 类风湿关节炎, Sjtoegren综合征, 多发性硬化, 视神经脊髓炎, 系统性红斑狼疮 详情

BAFF临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
UBP-1213 UBP-1213 临床一期 武汉华鑫康源生物医药有限公司, 上海君实生物医药科技股份有限公司 系统性红斑狼疮 详情
Blisibimod A-623; AMG-623 Anthera 详情
hCBE-11 hCBE-11 百健 详情
Rozibafusp alfa AMG-570; MEDI-0700 临床一期 安进 系统性红斑狼疮 详情
Tabalumab LY-2127399 临床二期 礼来制药 复发-缓解型多发性硬化, 皮肌炎, 类风湿关节炎, 自身免疫疾病, 系统性硬皮病, 多发性骨髓瘤, 结缔组织疾病, 幼年型类风湿性关节炎, 多发性硬化, 系统性红斑狼疮, 终末期肾脏病, 天疱疮 详情
Atacicept TACI-Ig 临床二期 Zymogenetics 免疫球蛋白a肾病, 类风湿关节炎, 多发性硬化, 视神经炎, 狼疮肾炎, 系统性红斑狼疮 详情

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