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B7-H2信息

英文名称:ICOS ligand
中文名称:ICOS配体
靶点别称:Inducible T-Cell Co-Stimulator Ligand,B7-like protein Gl50,B7-H2,B7RP-1,B7-related protein 1,B7H2,GL50,B7RP1,CD275 Antigen,ICOSL,Inducible T-Cell Costimulator Ligand,B7h,B7 Homologue 2,KIAA0653,Inducible T Cell Costimulator Ligand,Transmembrane Protein B7-H2 ICOS Ligand,ICOS-L,LICOS,B7 homolog 2,CD275,ICOSLG
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

B7-H2产品列表

 
评论(5)
B72-H5254|Human B7-H2 / ICOSLG Protein, Fc Tag
  1. 182XXXXXXX2
  2. 4人赞
  3. Fc标签的B7H2的SEC纯度确实不错,可以看到,单体的纯度有91%,另外,还有些聚集体,对于一个抗原,这个纯度很不错。
  4. >
  5. 2020-01-10
B72-H5221|Human B7-H2 / ICOSLG Protein, His Tag
  1. 151XXXXXXX5
  2. 1人赞
  3. 换了很多家的同类型的抗体,没想到就这样的最靠谱,无论是发货速度、售后服务,还是对产品的定价都无可挑剔,这简直就是广大科研工作者的梦中情人,这么优秀的品牌和试剂值得评价一番,希望品牌越来越好
  4. 2022-04-21
B72-H5221|Human B7-H2 / ICOSLG Protein, His Tag
  1. 188XXXXXXX0
  2. 0人赞
  3. 流式一直做不出来,也不知道什么原因,用了这个试剂后没想到证明了我的抗体是有问题的,虽然实验失败了,但是知道了原因也是进步,幸好有这个试剂,要不然真是一错再错了
  4. 2022-04-22
 

B7-H2 分子别名

ICOSLG,B7-H2,B7H2,B7RP-1,B7RP1,CD275,GL50,ICOS-L,ICOSL,LICOS,ICOS ligand

B7-H2 分子背景

ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

B7-H2 前沿进展

B7-H2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Prezalumab AMG-557; MEDI-5872; Anti-B7RP1-MAb; AMG-557/MEDI5872 安进 详情
Rozibafusp alfa AMG-570; MEDI-0700 临床一期 安进 系统性红斑狼疮 详情

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