Endoglin 靶点蛋白|抗体药物|临床药物信息

Endoglin信息

英文名称：Endoglin
中文名称：内皮因子
靶点别称：CD105 Antigen，CD105，END，ENG，Osler-Rendu-Weber Syndrome 1，HHT1，ORW1，Endoglin

上市药物数量：0
临床药物数量：1
最高研发阶段：临床二期

Endoglin产品列表

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产品库

在线 (1)

物种

Human (1)

标签

His Tag (1)

属性

Protein (1)

标记

Unconjugated (1)

货号	物种	产品描述	蛋白结构	纯度	活性
ENN-H52H9	Human	Human Endoglin / CD105 Protein, His Tag

Endoglin 分子别名

Endoglin,CD105,ENG,END

Endoglin 分子背景

Endoglin (ENG), endothelial glycoprotein, also known as CD105, is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. It regulates the responses associated with binding to transforming growth factor β1 egg (Activin-A), bone morphogenetic protein 2 (BMP-2), and bone morphogenetic protein 7 (BMP-7). Endoglin may be involved in autosomal dominant disease, such as hereditary hemorrhagic telangiectasia 1 (HHT1). Circulating soluble ENG is also elevated in pulmonary arterial hypertension(PAH) and is proposed to be a biomarker for the prognosis of group I PAH patients.

Endoglin 前沿进展

Endoglin临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Carotuximab	DE-122; TRC-105; Chimeric Antibody TRC-105; NSC#754227	临床二期	美国国家罗斯维尔公园癌症研究所	脑癌, 年龄相关性黄斑变性, 转移癌, 肝细胞癌, 非小细胞肺癌, 肺癌, 胶质瘤, 肝细胞腺瘤, 胎盘部位滋养细胞肿瘤, 绒毛膜癌, 输卵管癌, 输尿管肿瘤, 星形细胞瘤, 神经胶质肉瘤, 腹膜癌, 前列腺癌, 卵巢癌, 乳腺癌, 肉瘤, 去势抵抗性前列腺肿瘤, 实验性肝肿瘤, 少突神经胶质瘤, 妊娠滋养细胞疾病, 尿路上皮癌, 肿瘤, 胶质母细胞瘤, 滋养层肿瘤, 肾细胞癌, 血管肉瘤, 肝癌, 实体瘤	详情

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Endoglin