Recombinant Proteins iso9001 ISO13485
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Apo-A1信息

英文名称:Apolipoprotein A-I
中文名称:载脂蛋白A-I
靶点别称:Apolipoprotein A-I(1-242),APOA1,ProapoA-I,Apo-AI,Apolipoprotein A1,Apo(A),ApoA-I,Apolipoprotein A-I,HPALP2,Epididymis Secretory Sperm Binding Protein
上市药物数量:0
临床药物数量:3
最高研发阶段:临床三期

Apo-A1产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
AP1-H5225
Human
Human Apo-A1 Protein, His Tag
 
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Apo-A1 分子别名

Apolipoprotein A-I,APOA1,MGC117399

Apo-A1 分子背景

ApoA1 is also known as apolipoprotein A-I, ApoA-I , and is the major protein component of high density lipoprotein (HDL) in plasma. It has a specific role in lipid metabolism. Chylomicrons secreted from the intestinal enterocyte also contain ApoA1 but it is quickly transferred to HDL in the bloodstream. The protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterol acyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I was also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. In addition, it has been shown that ApoA1 is implicated in the anti-endotoxin function of HDL via interaction with lipopolysaccharide or endotoxin.

Apo-A1 参考文献

Apo-A1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Fx-5A Fx-5A 临床一期 Kinemed 心血管疾病 详情
SLN-360 临床一期 Silence Therapeutics Plc 血脂障碍, 高脂血症 详情
Pelacarsen TQJ-230; ISIS-681257; IONIS-681257 临床三期 Ionis Pharmaceuticals Inc, Akcea, Isis Pharmaceuticals 肾脏疾病, IIa型高脂蛋白血症, 心血管疾病 详情
CER-001 CER-001 临床三期 Cerenis 纯合子家族性高胆固醇血症, 动脉粥样硬化, 急性冠脉综合征, 低α脂蛋白血症, 脂类代谢紊乱 详情

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