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Alpha-fetoprotein信息
英文名称：Alpha-fetoprotein
中文名称：甲胎蛋白
靶点别称：Alpha-Fetoglobulin，AFP，Alpha-fetoprotein，Alpha Fetoprotein，Alpha-1-Fetoprotein，HPAFP，AFPD，FETA，alpha-Fetoproteins
中文名称：甲胎蛋白
靶点别称：Alpha-Fetoglobulin，AFP，Alpha-fetoprotein，Alpha Fetoprotein，Alpha-1-Fetoprotein，HPAFP，AFPD，FETA，alpha-Fetoproteins
上市药物数量：0
临床药物数量：7
最高研发阶段：临床二期
临床药物数量：7
最高研发阶段：临床二期
Alpha-fetoprotein 分子别名
Alpha-fetoprotein
Alpha-fetoprotein 分子背景
Alpha-fetoprotein(AFP) is the first tumor marker with clinical application value found by human. AFP has an ability to induce the immune escapes through inhibiting the function of dendritic cells, natural killer cells, and T lymphocytes. By in vitro modification, the immunogenicity and immune response of AFP could be enhanced. AFP-modified immune cell vaccine or peptide vaccine has displayed the specific antitumor immunity against AFP-positive tumor cells and laid a better foundation for the immunotherapy of liver cancer. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
Alpha-fetoprotein 前沿进展
Alpha-fetoprotein临床药物信息
| 英文名称 | 研发代码 | 研发阶段 | 公司 | 适应症 | 临床试验 |
|---|---|---|---|---|---|
| ADP-A2AFP | AFPc332T | 临床一期 | Adaptimmune Therapeutics Plc | 肝细胞癌 | 详情 |
| JWATM-203 | JWATM-203; JWATM203 | 临床二期 | 苏州药明巨诺生物科技有限公司 | 肝细胞癌 | 详情 |
| TAEST-1901 | TAEST-1901 | 临床一期 | 肝癌, 肿瘤 | 详情 | |
| SynOV1.1 | 临床二期 | 北京合生基因科技有限公司 | 实体瘤, 肝细胞癌 | 详情 | |
| ET1402L1-ARTEMIS T cells | 颐昂生物科技（北京）有限公司 | 详情 | |||
| ET1402L1-CART | AFP-CAR; ET-140202; AFP/ET-1402; ET1402; ET-1402 | 优瑞科 | 详情 | ||
| CPU-118 | CPU-118 | 临床一期 | 中国药科大学 | 肝癌, 实体瘤 | 详情 |
| Alpha fetoprotein targeted T-cell therapy (Adaptimmune) | AFP TCR (ADP-A2AFP); ADP-A2AFP; AFP TCR | 临床一期 | Adaptimmune | 肝癌 | 详情 |
