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IL-17B信息

英文名称:Interleukin-17 receptor B
中文名称:白细胞介素-17受体B
靶点别称:IL-17 receptor B,IL-17RB,Cytokine receptor-like 4,IL-17 receptor homolog 1,IL-17Rh1,IL17Rh1,Interleukin-17B receptor,IL-17B receptor
上市药物数量:0
临床药物数量:1
最高研发阶段:临床前

IL-17B产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
ILB-H5249
Human
Unconjugated,IL-17B,Human,His,HEK
ILB-H5257
Human
Human IL-17B Protein, Fc Tag
 
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IL-17B 分子别名

Interleukin-17B,Cytokine Zcyto7,Interleukin-20,IL-20,Neuronal interleukin-17-related factor,IL17B,IL20, NIRF, ZCYTO7

IL-17B 分子背景

IL-17B is a member of IL17 famaily, was originally described as a proinflammatory cytokine. IL-17B is produced by neutrophils and potentiates TNF-α effect on the production of cytokines and chemokines, such as IL-6, G-CSF, and CCL20, known to control immune cell trafficking to inflamed tissues. Interestingly, although IL-17B and IL-17E (IL-25) share a common receptor, IL-17RB, IL-17B, and IL-17E deficiency lead to opposite results in a model of acute colitis induced by dextran sulfate sodium. IL-17B inhibits IL-17E binding to IL-17RA– IL-17RB complexes on epithelial cells, and limits IL-17E-induced IL-6 production by colon epithelial cells.

IL-17B 前沿进展

IL-17B临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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