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SIGIRR产品列表

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货号 物种 产品描述 蛋白结构 纯度 活性
SIR-H5255
Human
Human SIGIRR Protein, Fc Tag (MALS verified)
 
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SIGIRR 分子别名

Single Ig IL-1-related receptor,Single Ig IL-1R-related molecule,Single immunoglobulin domain-containing IL1R-related protein,Toll/interleukin-1 receptor 8,TIR8

SIGIRR 分子背景

Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family. SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

SIGIRR 前沿进展

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