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KIR2DL4产品列表

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货号 物种 产品描述 蛋白结构 纯度 活性
KI4-H5255
Human
Human KIR2DL4 / CD158d Protein, Fc Tag
 
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KIR2DL4 分子别名

CD158d

KIR2DL4 分子背景

Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. Soluble HLA-G binds to KIR2DL4 in endosomes and activates the pathway of DNA-PKcs (DNA-dependent protein kinase, catalytic subunit)-AKT-NF-κB signals. The stimulation of the ITIM of KIR2DL4 protein brings about the recruitment and activation of non-receptor protein phosphatases Src homology 2 domain-containing tyrosine phosphatase (SHP)-1 and SHP-2, and the following inhibition of CD16/FcγRIIIa signaling pathway in human NK cells.

KIR2DL4 前沿进展

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