Glycoprotein E (VZV) 靶点蛋白|抗体药物|临床药物信息

Glycoprotein E (VZV)信息

英文名称：Envelope (E) protein
中文名称：包膜（E）蛋白
靶点别称：gE-1，Envelope glycoprotein E，gE

上市药物数量：0
临床药物数量：1
最高研发阶段：临床一期

Glycoprotein E (VZV)产品列表

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货号	物种	产品描述
GLE-V52H3	Varicella zoster virus	Varicella zoster virus (strain Oka vaccine) Envelope Glycoprotein E (gE), His Tag
RAS-T103	Varicella zoster virus	Mouse Anti-Varicella Zoster Virus Antibody IgG Titer Serologic Assay Kit (gE)
RAS-A102	Varicella zoster virus	Varicella Zoster Virus Glycoprotein E (VZV gE) ELISA Kit
VZV-M545	Mouse	Anti-Glycoprotein E (VZV) Antibody, Human IgG1 (4G2) (MALS verified)
VZV-M544	Mouse	Anti-Glycoprotein E (VZV) Antibody, Human IgG1 (1B10) (MALS verified)
RAS-T132	Varicella zoster virus	Human Anti-Varicella Zoster Virus Antibody IgG Titer Serologic Assay Kit (gE)
RAS-A135	Varicella zoster virus	Varicella Zoster Virus Glycoprotein E (VZV gE) ELISA Kit (For Vaccine Development)

GLE-V52H3|Varicella zoster virus (strain Oka vaccine) Envelope Glycoprotein E (gE), His Tag

136XXXXXXX5

24人赞

由同事推荐，购买了此蛋白，用于血清titer检测和表达产物检测。初步ELISA实验效果良好，上下平台的边界数据很明显，且蛋白性能较稳定。按照说明书中的稀释方法，就已经能满足大部分ELISA类型的实验需求了，损耗也不是很大。
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2022-08-11

RAS-T103|Mouse Anti-Varicella Zoster Virus Antibody IgG Titer Serologic Assay Kit (gE)

136XXXXXXX5

5人赞

购买此试剂盒与另一家进口试剂盒做比较。由于进口试剂盒价格高昂，货期长。故寻找国内替代品。使用相同的受gE刺激后的小鼠中提取的血清，进行平行测试。测试结果和进口试剂盒的表现基本一致，灵敏度的极限稍差一些，但是其实不影响实际测Titer的效果。是较好的进口试剂盒的替代品。且其中的试剂Dilution Buffer使用比进口试剂盒中ELISAPOT Dilution Buffer在使用上更明确与方便。
2022-08-17

GLE-V52H3|Varicella zoster virus (strain Oka vaccine) Envelope Glycoprotein E (gE), His Tag

138XXXXXXX5

0人赞

选择该蛋白主要用于免疫对照和细胞免疫研究中蛋白刺激对照，该产品具有良好的体内免疫原性和蛋白活性，可以用于细胞免疫FACS试验研究用。
2023-02-21

Glycoprotein E (VZV) 分子别名

Glycoprotein E (VZV) 分子背景

Varicella-zoster virus (VZV) is a neurotropic virus belonging to the Herpesviridae family. Primary VZV infection causes chickenpox and is followed by a life-long latent infection established mainly in the cranial and dorsal root ganglia. Reactivation of the virus is often associated with shingles (herpes zoster). Glycoprotein E (gE) is one of the known glycoproteins (gB, gC, gE, gH, gI, gK, gI) of VZV that is most abundantly expressed on the surface of virus and infected cells, playing an important role in viral replication and cell-to-cell spread. The strongly immunogenic gE can provide strong IgG signal in body fluid, which makes it ideal to be developed as an antigen for analysis of IgG antibodies. gE also demonstrates high potency as a vaccine immunogen and is formulated as the single viral envelope protein that constitutes the GSK VZV recombinant subunit vaccine Shingrix®.

Glycoprotein E (VZV) 前沿进展

Glycoprotein E (VZV)临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
SAR-440894	SAR-440894	临床一期	National Institute Of Allergy And Infectious Diseases (Niaid)	基孔贡亚病毒感染	详情

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Glycoprotein E (VZV)