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Angiopoietin-like 3信息

英文名称:Angiopoietin like 3
中文名称:血管生成素样蛋白-3
靶点别称:UNQ153/PRO179,Angiopoietin-5,Angiopoietin-like protein 3,Angiopoietin Like 3,Angiopoietin 5,ANGPT5,ANG-5,Angiopoietin-Related Protein 3,Angiopoietin-Like 3,FHBL2,ANL3,ANGPTL3
上市药物数量:0
临床药物数量:4
最高研发阶段:批准上市

Angiopoietin-like 3 分子别名

ANGPTL3,ANGPT5,ANG-5,Angiopoietin-5,FHBL2

Angiopoietin-like 3 分子背景

Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.

Angiopoietin-like 3 前沿进展

Angiopoietin-like 3临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
IONIS-ANGPTL3Rx ISIS-703802; PF-07285557 临床二期 Ionis Pharmaceuticals Inc 高甘油三酯血症, 纯合子家族性高胆固醇血症, 非酒精性脂肪肝, 二型糖尿病, IIa型高脂蛋白血症, I型高脂蛋白血症, 高脂蛋白血症, 血脂障碍, 心血管疾病, II型高脂蛋白血症, 高脂血症 详情
ARO-ANG3 ARO-ANG3 临床二期 Arrowhead Pharmaceuticals 高甘油三酯血症, 血脂障碍, II型高脂蛋白血症, 脂类代谢紊乱 详情
ARO-APOC3 ARO-APOC3 临床二期 Arrowhead Pharmaceuticals 高甘油三酯血症 详情

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