BMPR-1A 靶点蛋白|抗体药物|临床药物信息

BMPR-1A信息

英文名称：Bone morphogenetic protein receptor type-1A
中文名称：1A型骨形态发生蛋白受体
靶点别称：Bone Morphogenetic Protein Receptor Type 1A，EC 2.7.11，Activin receptor-like kinase 3，Bone morphogenetic protein receptor type-1A，ALK3，BMPR1A，Bone Morphogenetic Protein Receptor， Type IA，Serine/Threonine-Protein Kinase Receptor R5，ACVRLK3，BMPR-1A，SKR5，Activin A Receptor， Type II-Like Kinase 3，CD292 Antigen，EC 2.7.11.30，10q23del，CD292，BMP type-1A receptor，ALK-3，EC:2.7.11.30

上市药物数量：2
临床药物数量：1
最高研发阶段：批准上市

BMPR-1A产品列表

筛选结果

产品库

在线 (3)

物种

Human (3)

标签

属性

Protein (3)

标记

Unconjugated (3)

货号	物种	产品描述
AL3-H5228	Human	Human BMPR-1A / ALK-3 Protein, His Tag (MALS verified)
AL3-H5259	Human	Human BMPR-1A / ALK-3 Protein, Fc Tag
AL3-H52H9	Human	Human BMPR-1A / ALK-3 Protein, His Tag (MALS verified)

BMPR-1A 分子别名

BMPR-1A,ALK-3,ACVRLK3,CD292,SKR5

BMPR-1A 分子背景

The bone morphogenetic protein receptor, type IA is also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis.

BMPR-1A 前沿进展

BMPR-1A上市药物信息

英文名称	中文名称	研发代码	研发阶段	公司	最早商品名	最早批准国家	最早适应症	最早批准公司	最早批准日期	适应症	临床试验
DWP-431		DWP-431; rhBMP-2	批准上市	大熊制药株式会社	Novosis, Novosis-Dental	South Korea	牙槽骨质丢失	Daewoong Pharmaceutical Co Ltd	2013-01-01	牙槽骨质丢失, 椎间盘退化	详情
Dibotermin alfa		YM-484; rhBMP-2/CPM	批准上市	美敦力	Inductos	EU	胫骨骨折	Medtronic Biopharma Bv	2002-09-09	胫骨骨折, 牙齿损伤, 脊椎骨关节炎, 骨损伤, 骨关节炎, 桡骨骨折	详情

BMPR-1A临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Recombinant human bone morphogenetic protein 4 (Stemgen)	HS-214; hrBMP4	临床一期	Stemgen	闭塞性细支气管炎, 肺脏移植排斥, 胶质母细胞瘤, 肺疾病, 哮喘	详情

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BMPR-1A