登录 | 注册    关注公众号  
搜索

Angiopoietin-2信息

英文名称:Angiopoietin-2
中文名称:血管生成素-2
靶点别称:ANGPT2,Angiopoietin 2,ANG-2,Angiopoietin-2B,Angiopoietin-2a,Angiopoietin-2,Tie2-Ligand,AGPT2,ANG2
上市药物数量:0
临床药物数量:12
最高研发阶段:批准上市

Angiopoietin-2产品列表

 
评论(2)
AN2-H82E7|Biotinylated Human Angiopoietin-2 / ANGPT2 Protein, His,Avitag™
  1. 151XXXXXXX4
  2. 1人赞
  3. ANG2这个蛋白做elisa体外实验活性可以,网站上数据也比较齐全,相比SB的批间差更小。现在做细胞活性测试,希望效果也不错
  4. 2022-01-14
AN2-M52H3|Mouse Angiopoietin-2 / ANGPT2 Protein, His Tag
  1. 180XXXXXXX9
  2. 0人赞
  3. 活性及稳定性均较好。在用于抗体筛选过程中,体现出较好的筛选效果,且种属交叉检测效果显著。提高筛选的特异性及阳性率。
  4. 2021-11-04
 

Angiopoietin-2 分子别名

ANGPT2,AGPT2,ANG2,Angiopoietin-2

Angiopoietin-2 分子背景

Angiopoietin-2 is also known as ANGPT2, AGPT2, ANG2, and is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Ang2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel Palade bodies. Both Ang2 and the related Angiopoietin1 (Ang1) are ligands for the receptor tyrosine kinase Tie 2. Ang2 functions as a proangiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. Ang2 is required for postnatal vascular remodeling, and it cooperates with Ang1 during lymphatic vessel development. It mediates the upregulation of ICAM1 and VCAM1 on EC, which facilitates the adhesion of leukocytes during inflammation. Ang2 competitively inhibit Ang1-induced endothelial cell responses mediated by Tie2, and reduces vascular integrity. But the role of Ang2 is controversial since the opposite outcomes has been reported in other studies. Over-expression of Ang2 disrupts the vascular remodeling, induce endothelial cell apoptosis, and may play an important regulating role in tumor angiogenesis. Ang2 also promotes the neuronal differentiation and migration of subventricular zone progenitor cells.

Angiopoietin-2 前沿进展

Angiopoietin-2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
RG-6120 RG-6120 临床一期 罗氏 年龄相关性黄斑变性 详情
IBI-324 IBI-324 临床一期 Innovent Biologics (Usa), Inc 糖尿病黄斑水肿 详情
RO-7250284 RO-7250284 罗氏 详情
Nesvacumab REGN-910; SAR-307746 Regeneron Pharmaceuticals Inc, 赛诺菲 详情
Trebananib AMG-386; 20060439 安进, Takeda Pharmaceutical Co Ltd 详情
PF-4856884 CVX-060; CovX 060; PF-04856884 Covx Pharmaceuticals, 辉瑞 详情
MEDI-3617 ANG-2-mAb; MEDI-3617; Anti-ANG-2-mAb Medimmune 详情
Aflibercept/Nesvacumab REGN 910-3 Regeneron Pharmaceuticals Inc 详情
PF-5057459 CVX-241; CovX-241; PF-05057459 辉瑞制药有限公司 详情
Zansecimab LY-3127804 礼来制药 详情
Vanucizumab RG-7221; RO-5520985; B800Z06O8K (UNII code) 罗氏 详情
BI-836880 BI-836880 临床一期 Ablynx 头颈部鳞状细胞癌, 肿瘤, 湿性黄斑变性, 鳞状细胞癌, 非小细胞肺癌 详情
ASKG-712 AM-712; ASKG-712 临床一期 Askgene Pharma 湿性黄斑变性, 年龄相关性黄斑变性 详情

消息提示

请输入您的联系方式,再点击提交!

确定