Recombinant Proteins iso9001 ISO13485
 > 【Angiopoietin-2】重组蛋白信息


靶点别称:ANGPT2,Angiopoietin 2,ANG-2,Angiopoietin-2B,Angiopoietin-2a,Angiopoietin-2,Tie2-Ligand,AGPT2,ANG2

Angiopoietin-2 分子别名


Angiopoietin-2 分子背景

Angiopoietin-2 is also known as ANGPT2, AGPT2, ANG2, and is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Ang2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel Palade bodies. Both Ang2 and the related Angiopoietin1 (Ang1) are ligands for the receptor tyrosine kinase Tie 2. Ang2 functions as a proangiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. Ang2 is required for postnatal vascular remodeling, and it cooperates with Ang1 during lymphatic vessel development. It mediates the upregulation of ICAM1 and VCAM1 on EC, which facilitates the adhesion of leukocytes during inflammation. Ang2 competitively inhibit Ang1-induced endothelial cell responses mediated by Tie2, and reduces vascular integrity. But the role of Ang2 is controversial since the opposite outcomes has been reported in other studies. Over-expression of Ang2 disrupts the vascular remodeling, induce endothelial cell apoptosis, and may play an important regulating role in tumor angiogenesis. Ang2 also promotes the neuronal differentiation and migration of subventricular zone progenitor cells.

Angiopoietin-2 参考文献


英文名称 研发代码 研发阶段 公司 适应症 临床试验
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Vanucizumab RG-7221; RO-5520985; B800Z06O8K (UNII code) 临床二期 罗氏 实体瘤, 肿瘤, 结直肠癌 详情
Faricimab RG-7716; RO-6867461 临床三期 罗氏 黄斑水肿, 糖尿病黄斑水肿, 湿性黄斑变性, 视网膜静脉阻塞, 糖尿病, 脉络膜新生血管化, 年龄相关性黄斑变性 详情